亜酸化窒素の放出のための支架としてデンドリマー

Nathan A Stasko¹, Mark H Schoenfisch

¹Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.

Journal of the American Chemical Society

|June 22, 2006

まとめ

研究者らは,新しい酸化窒素 (NO) を放出するデンドリマー結合体を開発した. これらの dendrimersは,強化されたNO貯蔵容量と持続的な放出を示し,改善されたNO配送システムを提供します.

科学分野:

ポリマー化学のポリマー化学について
材料科学材料科学とは
ナノテクノロジーナノテクノロジー

背景:

酸化窒素 (NO) は,治療の可能性のある重要なシグナル伝達分子です.
NOの不安定性のために,効果的なNO配送システムを開発することは困難です.
デンドリマーは,薬物投与アプリケーションの汎用性のある支架を提供します.

研究の目的:

酸化窒素 (NO) を放出するデンドリマー結合体を合成し,特徴づけること.
これらの新材料のNO貯蔵容量と放出運動を評価する.
先進的なNO貯蔵・配送システムとしてのデンドリマーの可能性を調査する.

主な方法:

3世代と5世代ポリプロピレニミンデンドリマー (DAB-Am-16とDAB-Am-64) をアミンの機能性で改造.
高圧 (5 atm) の下でN-ディアゼニウムジオラートドナーを使用して,デンドリマー基板にNOをロードする.
生理学的条件下 (pH 7.4, 37°C) のNO貯蔵容量とインビトロ放出運動の特徴.

主要な成果:

二次アミンデンドリマー結合体は,高いNO貯蔵能力 (最大5.6マイクロモールNO/mg) を示した.
NOの放出は陽子によって開始され,生理学的条件下で自発的に発生しました.
持続的なNO放出 (>16h) が観察され,小分子対比よりも大幅に長く, dendritic 効果を示しています.

結論:

ポリプロピレニミンデンドリマーは,強力なNOを放出する結合体を生成するために効果的に機能化することができます.
これらのデンドリマー結合体は,マクロ分子NOドナーの重要な進歩を表し,優れた貯蔵と持続的な放出を提供します.
デンドリマーの多価性質は,多様なNO配送アプリケーションのための多機能プラットフォームの開発を可能にします.

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