バイオチン・ストライプ・アビジン技術に基づく人工的移転水酸化酵素:宿主タンパク質の飽和変異による選択性を微調整する

Christophe Letondor1, Anca Pordea, Nicolas Humbert

  • 1Institute of Chemistry, University of Neuchâtel, Av. Bellevaux 51, CP 2, CH-2007 Neuchâtel, Switzerland.

まとめ

研究者は,ストレプタヴィジン内のバイオチニル化金属複合体を用いて,高度に選択的なケトン還元のための人工酵素を作成しました. 遺伝子組み換えにより精密調整された選択性により,トランスファー水素化によるエナンチオ濃縮アルコールの効率的な生産が可能になります.

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