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小児におけるアステミゾールの過量投与事故
K Hoppu1, T Tikanoja, P Tapanainen
1Children's Hospital, 2nd Department of Paediatrics, Helsinki, Finland.
Lancet (London, England)
|August 31, 1991
まとめ
小児における偶然のアステミゾール中毒は,危険な心拍の問題を引き起こす可能性があります. アステミゾール過量投与の小児患者,特に他のH1抗ヒスタミン薬を服用している患者にとって,病院での注意深いモニタリングは不可欠です.
科学分野:
- 小児の毒理学について
- 心臓病学 心臓病学
- 薬理学 薬理学とは
背景:
- アステミゾールは,選択的なH1-ヒスタミン受容体対抗剤です.
- 小児の意外な過剰摂取は,重大な毒性を引き起こす可能性があります.
- 心臓の有害事象は,抗ヒスタミンの過剰投与で懸念されるものです.
研究 の 目的:
- 小児における偶然のアステミゾール中毒の症例を報告する.
- アステミゾール過量投与の臨床表現と心臓への影響を記述する.
- 小児アステミゾール中毒の適切な管理を推奨する.
主な方法:
- 国立毒害管理センターから報告された遡及的ケースシリーズ.
- 患者の人口統計,摂取量,臨床結果の分析.
- QTc間隔を含む心臓の毒性に対する電気心臓図 (EKG) 監視.
- 薬物の濃度測定は,特定のケースで実施される.
主要な成果:
- 1歳7ヶ月から3歳4ヶ月までの1歳7ヶ月から3歳4ヶ月までの子どもで,アステミゾール過量投与の事故が6件発生しました.
- 摂取用量は2.5 mg/kgから16.7 mg/kgの範囲で,推奨値を大幅に上回りました.
- 延長されたQTc間隔 (心臓の毒性の兆候) は,利用可能なECGを持つ5人の子供全員で観察されました.
- 1人の子供に重度の心房不律症が発症しました.
結論:
- 意外なアステミゾール過量投与を受けた幼い子供には,病院での注意深いモニタリングが必要です.
- QTc延長や心律乱などの心臓毒性は,重大なリスクである.
- 同様の監視は,他の選択的H1-ヒスタミン受容体対抗剤の過剰投与の場合には正当化される可能性があります.
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