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ATMは,V(D) J再結合時にDNAの二重鎖断裂複合体を安定させる

Andrea L Bredemeyer1, Girdhar G Sharma, Ching-Yu Huang

  • 1Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri 63110, USA.

Nature
|June 27, 2006
PubMed
まとめ

アタキシア・テランジエクタジア変異 (ATM) タンパク質キナーゼは,DNA修復とDNA二重鎖断裂 (DSB) に対する細胞反応に不可欠です. ATM欠乏症はDNA修復を阻害し,がん,特にリンパ性悪性腫瘍のリスクを高めます.

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