断食時の血Cペプチドとインスリンにおける,グルコース耐性と血圧との関係における民族的差異
J K Cruickshank1, J Cooper, M Burnett
1Department of Medicine, Northwick Park Hospital, Harrow, Middlesex, UK.
Lancet (London, England)
|October 5, 1991
まとめ
非インスリン依存性糖尿病 (NIDDM) の民族的差異は,血圧ではなく,インスリン分泌と肝臓クリアランスの変動と関連しています. ダイエットなどの要因は,これらのNIDDM率の格差を説明する可能性があります.
科学分野:
- エンドクリノロジー エンドクリノロジー
- メタボリック疾患
- 人口の健康 人口の健康
背景:
- 非インスリン依存型糖尿病 (NIDDM) と高血圧の罹患率は,民族によって著しく異なります.
- これらの民族的格差の根本的なメカニズムは,ほとんど解明されていないままです.
研究 の 目的:
- NIDDM率における民族的差異の背後にあるメカニズムを調査する.
- 異なる民族集団におけるインスリン分泌,Cペプチドレベル,およびNIDDMとの関係を調べる.
主な方法:
- 血Cペプチドとインスリン濃度は,アフリカ系カリブ系,グジャラティ系インディアン,白人ヨーロッパ系314人の成人 (45-74歳) に測定された.
- 禁食と経口のグルコース耐性テストが行われました.
- NIDDMの年齢調整された罹患率を計算し,統計分析により新しいNIDDMの予測要因が特定されました.
主要な成果:
- NIDDMの流行率は,白人ヨーロッパ人 (3%) と比べて,アフリカ系カリブ (29%) とグジャラティ系インディアン (30%) のグループで著しく高かった.
- 断食中のCペプチドとインスリンレベルは,新しいNIDDMの強力な独立した予測因子であり,民族集団の違いを考慮した.
- インスリン分泌指数と血圧または高血圧との関連は見つかりませんでした.
結論:
- NIDDMの割合の民族的差異は,主にインスリン分泌と肝臓クリアランスの違いによって引き起こされ,食生活要因の影響を受ける可能性があります.
- 血圧ではなくインスリン分泌が,NIDDMにおける民族差異の決定要因である.
- インスリン代謝における食事脂肪の役割に関するさらなる研究が必要である.
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