アンチトロンビンIIIと動脈疾患
T W Meade1, J Cooper, G J Miller
1MRC Epidemiology and Medical Care Unit, Northwick Park Hospital, Harrow, UK.
Lancet (London, England)
|October 5, 1991
まとめ
低レベルと高レベルのアンチトロンビンIIIの両方が,動脈疾患のリスクを高めます. この前向きな研究では,極度のアンチトロンビンIII濃度を持つ男性では,中程度の濃度を持つ男性と比較して,動脈疾患による死亡率が高かった.
科学分野:
- 心血管科学 心血管科学
- 血液学 ヘマトロジ
背景:
- 横断的な研究では,抗トロンビンIIIレベルと動脈疾患のリスクとの関連が示されています.
- 低レベルのアンチトロンビンIIIと高レベルのアンチトロンビンIIIは,特に心不全性疾患 (IHD) のリスクの増加と関連しています.
研究 の 目的:
- アンチトロンビンIII濃度と,その後の動脈疾患による死亡との関係を将来的に調査する.
主な方法:
- ノースウィック・パーク・ハート・スタディでは,893人の男性を前向きに分析した.
- アンチトロンビンIIIレベルは評価され,因子VIIの活性とプラズマフィブリノゲンレベルと相関しました.
主要な成果:
- 抗トロンビンIII濃度と,より高い因子VII活性とプラズマフィブリノゲンとの間には直接的な相関が観察されました.
- 動脈疾患による死亡率は,アンチトロンビンIII分布の最下位と最上位3分の1で,中位3分の1と比較して高かった.
結論:
- 非常に低いレベルと非常に高いレベルのアンチトロンビンIIIは,動脈疾患による死亡のリスクの増加と関連しています.
- これらの発見は,抗トロンビンIIIレベルと動脈疾患の死亡率の間のU型関係の可能性を強調しています.
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