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ダイオキシンで汚染された化学工場の労働者の癌による死亡率
1Centre for Chemical Workers' Health, Department of Health, Hamburg, Germany.
Lancet (London, England)
|October 19, 1991
まとめ
この研究では,ダイオキシン (2,3,7,8-テトラクロロディベンゾ-p-ダイオキシンまたはTCDD) に曝露した除草剤工場の労働者を追跡した. 結果は,TCDDの曝露が男性におけるがん死亡率の増加と,女性における乳がんの増加と関連していることを示しており,その発がん性を支持しています.
科学分野:
- 職業衛生は,健康に関するものです.
- 毒理学 毒理学 毒理学
- エピデミオロジー エピデミオロジー
背景:
- ダイオキシン (2,3,7,8-テトラクロロディベンゾ-p-ダイオキシンまたはTCDD) は,除草剤の生産における汚染物質である.
- TCDDはクロラックネを引き起こすことが知られているが,ヒトの発がん性については依然として議論されている.
研究 の 目的:
- ドイツの除草剤製造工場でTCDDにさらされた労働者の死亡パターンを調査する.
- このコホートにおけるTCDD曝露とがん死亡率の関連性を評価する.
主な方法:
- 1989年まで生命状態が決定された1583人の労働者 (1952年−1984年) の死亡率の追跡調査.
- 全癌および特定の癌の標準死亡率 (SMR) の計算,国家統計とガス労働者コホートと比較.
- 分析は雇用期間,開始日,およびTCDD被曝の疑いレベルによって層分かれています.
主要な成果:
- 男性の全がん死亡率は高かった (SMR 1.24-1.39).
- 癌による死亡率の増加は,長期の雇用期間,早期の就業開始日,および高いTCDD曝露を有する男性で観察されました.
- 女性では乳がんによる死亡率の増加が認められた (SRM=2.15),しかし,全体的ながんリスクは増加しなかった.
結論:
- この発見は,TCDDがヒトの発がん物質であるという仮説を裏付けている.
- 除草剤の生産におけるTCDDに対する職業的曝露は,男性におけるがんリスクの増加と,女性における乳がんリスクの増加と関連しています.
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