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クロロフェノキシ除草剤とクロロフェノールに曝露した労働者における癌による死亡率
R Saracci1, M Kogevinas, P A Bertazzi
1Unit of Analytical Epidemiology, International Agency for Research on Cancer, Lyon, France.
Lancet (London, England)
|October 26, 1991
まとめ
クロロフェノキシ除草剤の職業的曝露は,特にスプレーヤーの軟組織サルコマの癌のリスクを増やす可能性があります. ダイオキシン汚染の関連と役割を確認するためにさらなる研究が必要である.
科学分野:
- 職業衛生は,健康に関するものです.
- エピデミオロジー エピデミオロジー
- 毒理学 毒理学 毒理学
背景:
- 以前の研究では,クロロフェノキシ除草剤に対する職業的曝露と,軟組織肉腫やノンホッジキンリンパ腫を含む癌のリスクの増加との関連が示唆されています.
- これらの除草剤の2,3,7,8-テトラクロロディベンゾ-p-ダイオキシン (TCDD) による汚染は,潜在的な懸念事項である.
研究 の 目的:
- クロロフェノキシ除草剤に曝露した労働者の国際的なコホートの中でがんによる死亡率を調査する.
- TCDDの潜在的汚染を考慮して,職業上の除草剤曝露と特定の癌の間の関連性を評価する.
主な方法:
- 10カ国から18,910人の生産労働者とスプレーヤーを対象とした歴史的なコホート研究.
- アンケート,記録,職業履歴を通じて被曝の評価; 比較のために因果的な国家死亡率を用いた死亡率の分析.
主要な成果:
- すべての原因による死亡率,全身新生体,一般的な上皮がん,リンパ腫の過剰な増加はありません.
- 軟組織肉腫 (SMR 196) の統計的に非有意な二重過度のリスク.
- 暴露後10~19年 (SMR 606) において,軟組織肉腫のリスクが6倍に増加し,スプレーヤーでは9倍に増加した (SMR 882). ,甲状腺,内分泌,鼻の癌のリスクも増加しており,小数値に基づいています.
結論:
- スプレーヤーの間で観察された軟組織サルコマの過剰は,クロロフェノキシ除草剤の潜在的な因果的な役割と一致しています.
- 過剰なリスクは,TCDDに汚染された除草剤と特異的に関連しているように見えず,他の被曝因子に関するさらなる調査を正当化しています.
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