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Updated: Jul 18, 2026

Split-and-pool Synthesis and Characterization of Peptide Tertiary Amide Library
13:37

Split-and-pool Synthesis and Characterization of Peptide Tertiary Amide Library

Published on: June 20, 2014

TMP-亜鉛酸の構造と反応経路:アミド塩基かアルキル塩基か?

Masanobu Uchiyama1, Yotaro Matsumoto, Daisuke Nobuto

  • 1Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan. uchiyama@mol.f.u-tokyo.ac.jp

Journal of the American Chemical Society
|July 6, 2006
PubMed
まとめ

この研究は,指向性オーソメタレーション (DoM) 反応のための新しいTMP-Zn-ate反応剤を調査しています. 発見は,TMPリガンドが,機能化された芳香化合物を合成する際に,運動的に有利なデプロトネーションの鍵であることを明らかにしています.

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Brønsted-Lowry Acids and Bases02:16

Brønsted-Lowry Acids and Bases

In 1923, the Brønsted–Lowry definition of acids and bases was proposed by Johannes Brønsted and Thomas Lowry. According to this theory, a Brønsted acid is defined as a species that donates a proton in a chemical reaction and gets converted to its conjugate base. A Brønsted base is defined as a species that accepts a proton in a chemical reaction and gets converted into its conjugate acid. These transfers of protons are caused by the displacement of electrons in these reactions, which is...
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Acidity of 1-Alkynes


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Introduction
Alkylation of terminal alkynes with primary alkyl halides in the presence of a strong base like sodium amide is one of the common methods for the synthesis of longer carbon-chain alkynes. For example, treatment of 1-propyne with sodium amide followed by reaction with ethyl bromide yields 2-pentyne.
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Preparation of 1° Amines: Gabriel Synthesis

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Strong bases like NaOH or KOH deprotonate the phthalimide to form the corresponding anion, which acts as a nucleophile. Further, the anion attacks an...