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Updated: Aug 3, 2026

An Orthotopic Mouse Model of Anaplastic Thyroid Carcinoma
07:01

An Orthotopic Mouse Model of Anaplastic Thyroid Carcinoma

Published on: April 17, 2013

甲状腺ホルモン受容体のアロステリックメカニズムをターゲットにすることで作成された機能的に直角なリガンド受容体ペア

A Quamrul Hassan1, John T Koh

  • 1Department of Chemistry and Biochemistry, University of Delaware, Newark, Delaware 19716, USA.

Journal of the American Chemical Society
|July 6, 2006
PubMed
まとめ

新種の合成ホルモンアナログであるQH2は,ワイルド型受容体に影響を与えることなく,変異性甲状腺ホルモン受容体 (TRbeta H435A) を選択的に活性化します. この発見は,核受容体を使用して精密な遺伝子調節のための新しい可能性を提供します.

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