伸縮性心筋病症におけるミトラルパンフレットリモデリング
Tomasz A Timek1, David T Lai, Paul Dagum
1Department of Cardiothoracic Surgery, Stanford University School of Medicine Stanford, California 94305-5247, USA.
Circulation
|July 6, 2006
まとめ
タチカルディア誘発の心筋症候群は,縁の近くでの改造によるミトラ弁の葉書が伸びる原因であり,縛り付けや形状の変化ではありません. この改造は,心筋疾患におけるミトラル吐と関連しています.
科学分野:
- 心血管科学の研究について
- 心臓のメカニズム 心臓のメカニズム
- バイオメディカルエンジニアリング
背景:
- 哺乳類のミトラル弁の用紙には,構成と構造の地域的な違いがあります.
- 伸縮性心筋症がミトラル小葉の形状と幾何学に与える影響は不明である.
研究 の 目的:
- タヒカルディア誘発性心筋症 (TIC) がミトラ弁の形状,幾何学,および地域改造にどのように影響するかを調査する.
- TIC誘発的機能性ミトラル吐 (FMR) で,チラシの結合または重要な形状の変化が発生するかどうかを判断する.
主な方法:
- 9頭の羊のミトラアヌルスに無線不透明マーカーと小葉書を埋め込みました.
- 誘発性心筋病症と,急速なペースを介して機能的なミトラル吐.
- 二平面ビデオ光鏡とエコーカルディオグラフィーを用いて,小冊子の長さ,セグメントの長さ,および位移を測定しました.
主要な成果:
- 前頭部ミトラリーフレット (AML) と後頭部ミトラリーフレット (PML) の全長が,ペーシング後,著しく増加した.
- 重要な地域改造は,辺の付近の小冊子セグメント (AML S4とPML S5) でのみ観察されました.
- AMLの形状やパンフレット・テザリングの変更は検出されなかった.
結論:
- タチカルディア誘発の心筋症候群は,側頭葉の縁の地域的な改造を経由して,側頭葉の延長につながる.
- 心筋病変におけるミトラル吐は,フリフレットの改造を含み,FMRの純粋な"機能的"説明に異議を唱える.
- 研究結果は,単純環状膨張を超えて,心筋病におけるミトラル吐の構造的基礎を示唆しています.
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