ノルウェーのB群髄膜球菌病に対する外膜膀ワクチンの効果
G Bjune1, E A Høiby, J K Grønnesby
1National Institute of Public Health, Oslo, Norway.
Lancet (London, England)
|November 2, 1991
まとめ
髄膜炎球菌B外膜ワクチンは,ノルウェーの大規模な試験で57.2%の有効性を示しました. 予防接種は保護的ですが,ワクチンは保護的ではありません.
科学分野:
- 感染症 感染症は感染症です.
- ワクチン学 ワクチン学
- エピデミオロジー エピデミオロジー
背景:
- ノルウェーは,北ヨーロッパで Meningokokk病の発生率が最も高い国です.
- 血清群Bの髄膜球菌は80%の症例を引き起こし,高死亡率は約10%である.
研究 の 目的:
- 血清群Bの髄膜球菌疾患に対する外部膜膀 (OMV) ワクチンの有効性を評価する.
- ワクチンの保護レベルが公的ワクチン接種プログラムを正当化しているかどうかを判断する.
主な方法:
- ノルウェーで171,800人の中学生を対象とした大規模,ランダム化,ダブルブラインド,プラセボ制御の有効性試験です.
- 学校はランダム化ユニットでした.
- 13歳から21歳の学生の脳膜炎および/またはセプチセミアの疑いのある症例の緊急報告.
主要な成果:
- グループBの髄膜球菌による重度の全身疾患の89例が確認されました.
- この試験では36件の症例が報告されました (ワクチン接種を受けた学校11校,プラセボを受けた学校24校).
- 計算されたワクチンの有効性は57.2% (p = 0.012) でした.
結論:
- 髄膜球菌BのOMVワクチンは,グループBの髄膜球菌疾患に対する保護を与えました.
- 観察された有効性は,公衆ワクチン接種プログラムを正当化するのに不十分でした.
- ワクチンの有効性を向上させるため,または代替戦略を探るため,さらなる研究が必要になる可能性があります.
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