関連する実験動画
Updated: Jul 28, 2026

14:09
In vitro Functional Characterization of Mouse Colorectal Afferent Endings
Published on: January 21, 2015
電気的に刺激されたネオアナスフィンクターの発達
N S Williams1, J Patel, B D George
1Surgical Unit, Royal London Hospital, Whitechapel, UK.
Lancet (London, England)
|November 9, 1991
まとめ
この研究は,グラシリスの筋肉の転移と電気刺激を改変することによって, incontinenceのための外科的テクニックを改良し,患者の incontinenceを成功裏に回復し,永久性ストーマの代替案を提供しました.
科学分野:
- 手術のイノベーションです.
- リコンストラクティブ・外科手術は,
- バイオメディカルエンジニアリング
背景:
- 転移したグラシリス筋を用いたネオアナス臓の手術創出は,筋疲労による課題に直面しています.
- 以前の筋肉を疲労耐性型に変換する試みは矛盾した結果をもたらした.
研究 の 目的:
- 電気的に刺激された転置グラシリス筋を用いたネオアナルの門器の技術への修正を記述する.
- incontinenceの患者の長期的な機能的アウトカムを改善するために.
主な方法:
- 完全に埋め込まれた刺激器を搭載したトランスポーズされたグラシリス筋は,急速な筋収縮を遅い筋収縮に変換します.
- 血管の遅延,直接的な神経刺激,中断的な高周波刺激が組み込まれています.
- アナルスフィンクターが欠乏した20人の患者と,アノレクトル欠損/切除の12人の患者に適用されました.
主要な成果:
- 2〜4種類の特定の改変を組み込んだ改変されたテクニックは,以前の方法 (0-1種類の改変) に比べて,失敗が著しく少なくなった.
- 重度の排便不便症の患者でコンティネンスが回復した.
結論:
- 強化されたネオアナスフィンクターのテクニックは, incontinenceに有効な解決策を提供し,永久的なストーマの必要性を潜在的に回避します.
- 追加の改変により,スフィンクターの再建のための筋肉の転置の成功率を大幅に改善します.
関連する概念動画
Action Potentials
Overview
Synaptic Signaling
Neurons communicate at synapses, or junctions, to excite or inhibit the activity of other neurons or target cells, such as muscles. Synapses may be chemical or electrical.
Most synapses are chemical, meaning an electrical impulse or action potential spurs the release of chemical messengers called neurotransmitters. The neuron sending the signal is called the presynaptic neuron, and the neuron receiving the signal is the postsynaptic neuron.
The presynaptic neuron fires an action potential that...
Most synapses are chemical, meaning an electrical impulse or action potential spurs the release of chemical messengers called neurotransmitters. The neuron sending the signal is called the presynaptic neuron, and the neuron receiving the signal is the postsynaptic neuron.
The presynaptic neuron fires an action potential that...
Action Potential
Neurons communicate by firing action potentials—the electrochemical signal that is propagated along the axon. The signal results in the release of neurotransmitters at axon terminals, thereby transmitting information to the nervous system. An action potential is a specific "all-or-none" change in membrane potential that results in a rapid spike in voltage.
Membrane potential in neurons
Neurons typically have a resting membrane potential of about -70 millivolts (mV). When they receive...
Membrane potential in neurons
Neurons typically have a resting membrane potential of about -70 millivolts (mV). When they receive...
Electrical Synapses
Electrical synapses found in all nervous systems play important and unique roles. In these synapses, the presynaptic and postsynaptic membranes are very close together (3.5 nm) and are actually physically connected by channel proteins forming gap junctions.
Gap junctions allow the current to pass directly from one cell to the next. In contrast, in the chemical synapse, the neurotransmitters carry the information through the synaptic cleft from one neuron to the next. They consist of two...
Gap junctions allow the current to pass directly from one cell to the next. In contrast, in the chemical synapse, the neurotransmitters carry the information through the synaptic cleft from one neuron to the next. They consist of two...
Action Potential
Neurons communicate by firing action potentials—the electrochemical signal that is propagated along the axon. The signal results in the release of neurotransmitters at axon terminals, thereby transmitting information to the nervous system. An action potential is a specific "all-or-none" change in membrane potential that results in a rapid spike in voltage.
Membrane potential in neurons
Neurons typically have a resting membrane potential of about -70 millivolts (mV). When they receive...
Membrane potential in neurons
Neurons typically have a resting membrane potential of about -70 millivolts (mV). When they receive...
Neuronal Communication
Neurons, the fundamental units of the brain and nervous system, communicate through complex electrochemical signals that underpin all cognitive and bodily functions. This communication is primarily facilitated by a process involving the generation and propagation of an action potential along the axon of the neuron. When the internal electrical charge of a neuron surpasses a certain threshold, an action potential is triggered. This rapid change in voltage travels swiftly along the axon to the...

