ヘリコバクター・パイロリ菌に関連した胃炎と,一次性B細胞胃リンパ腫
A C Wotherspoon1, C Ortiz-Hidalgo, M R Falzon
1Department of Histopathology, University College and Middlesex School of Medicine, London, UK.
Lancet (London, England)
|November 9, 1991
まとめ
ヘリコバクター・パイロリ感染症は,胃粘膜関連リンパ性組織 (MALT) の獲得につながる可能性があります. この獲得されたMALTは,胃がんの一般的な胃がんである胃のMALTリンパ腫の発症の前駆体である.
科学分野:
- 胃腸内科 胃腸内科
- 腫瘍学 腫瘍学
- 免疫学 免疫学とは
背景:
- 正常な胃粘膜にはリンパ性組織が欠けているが,原発性胃リンパ腫はしばしば粘膜関連リンパ性組織 (MALT) を模倣する.
- 胃リンパ性組織は,典型的にはヘリコバクター・パイロリ感染症に対する反応として獲得されます.
- ヘリコバクター・パイロリ感染症は,胃MALTリンパ腫の発症と強く関連しています.
研究 の 目的:
- ヘリコバクター・パイロリ感染症と胃リンパ性組織の獲得との関係を調査する.
- 胃MALTリンパ腫の患者におけるヘリコバクター・パイロリ感染症の有病率を決定する.
- 胃ALTリンパ腫の病原性における獲得された胃ALTの役割を確立する.
主な方法:
- H. pyloriに関連した胃炎を患った450人の患者の胃バイオプシの組織病理学的検査.
- 粘膜のリンパ性卵泡とBリンパ球の上細胞の浸透を特定する.
- 胃MALTリンパ腫の110例におけるH. pylori感染状態の分析.
主要な成果:
- H. pyloriの胃炎を患った450人の患者のうち125人 (27.8%) が粘膜リンパ性毛細部を示した.
- 8人の患者はBリンパ球が上皮に浸透し,MALTの特徴的な特徴を示した.
- ヘリコバクター・パイロリ菌感染症は,胃MALTリンパ腫の110例のうち101例 (92%) で検出されました.
結論:
- 胃MALTは,ヘリコバクター・パイロリ感染症に対する反応として獲得されます.
- 既得の胃MALTは,胃MALTリンパ腫の発症の重要な背景として機能する.
- H. pyloriの根絶は,胃のMALTリンパ腫を予防するための潜在的な戦略かもしれません.
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