非アドレネルジック,非コレネルジック神経系と,喘息患者および正常な被験者の夜間呼吸道カリバー
T W Mackay1, M F Fitzpatrick, N J Douglas
1Department of Medicine, City Hospital, Edinburgh, UK.
Lancet (London, England)
|November 23, 1991
まとめ
咳や喘息のような夜間喘息の症状は,朝の非アドレナergic,非コレナergic (NANC) 神経機能の低下に起因する可能性があります. この研究では,NANCシステムの変異を調査し,夜間支末管収縮との潜在的な関連性を明らかにしました.
科学分野:
- 呼吸器医学とは
- 神経免疫学 神経免疫学とは
- 肺生理学 肺生理学とは
背景:
- 咳や喘息など,夜間喘息の症状は,喘息患者によく見られる.
- パラシンパティックトーンが上昇しただけでは,夜間支末管の収縮を完全に説明することはできません.
研究 の 目的:
- ブロンキーの滑らかな筋肉を神経化する非アドレナergic,非コレナergic (NANC) 神経経路の機能の夜間変化を調査する.
- 早朝のNANCシステムの阻害が夜間支柱管収縮に寄与するかどうかを判断する.
主な方法:
- 評価されたNANC機能は,カプサイシン (NANCの刺激剤) の bronchodilator効果を0400hと1600hで比較することによって評価されました.
- 被験者は12人の正常な個人と12人の軽度の喘息患者を含め,パラシンパシーおよびベータアドレナージックブロックの後にテストされました.
- 支管管拡張効果は振動抵抗 (Ros) の変化として測定され,試験設計はランダム化され,ダブルブラインドであった.
主要な成果:
- カプサイシンへの反応として, bronchodilatationは,正常な被験者および喘息患者の両方において,0400hに比べて1600hで有意に大きかった.
- 正常な被験者は,Rosの9%の減少を16:00hで示し, -2%の減少を0400hで示した (p <0.001).
- 喘息患者では,Rosの1%の減少が16:00hで, -7%の減少が0400hで示されました (p = 0.001).
結論:
- 研究結果は,NANC神経機能が朝早くに低下することを示唆しています.
- このNANC機能の阻害は,喘息で観察される夜間筋縮に寄与する要因である可能性があります.
- NANCシステムの調節に関するさらなる研究は,夜間喘息制御のための新しい治療戦略を提供することができます.
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