ネズミTリンパ球CD2抗原のドメイン1の構造

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ネズミTリンパ球CD2抗原のドメイン1の構造

P C Driscoll¹, J G Cyster, I D Campbell

¹Department of Biochemistry, University of Oxford, UK.

Nature

|October 24, 1991

まとめ

CD2アンチゲンである.

科学分野:

免疫学と構造生物学.
細胞表面受容体の構造と機能を研究する.

背景:

CD2抗原は,T-リンパ球の相互作用において極めて重要であり,第1ドメイン (ドメイン1) を通して粘着を媒介する.
CD2ドメイン1の構造については,矛盾するモデルが存在します:免疫グロブリン (Ig) の折りたたみとアルファヘリックスとベータ鎖の交替.
CD2ドメイン1は,免疫グロブリンスーパーファミリー (IgSF) の配列ベースの割り当てのための重要なテストとして機能します.

研究の目的:

CD2ドメインの構造的曖昧さを解消するために 1.
IgSFタンパク質構造のシーケンスベースの予測を検証する.

主な方法:

ネズミのCD2ドメイン1がEscherichia coliで発現する.
低解像度の溶液構造の決定は,NMR光譜を用いて行われます.

主要な成果:

CD2ドメイン1の低解像度構造は,NMRによって決定された.
これらの構造データは,矛盾する構造モデルを評価するための基礎を提供します.

結論:

CD2ドメイン1の決定された構造は,その折りたたみに関する重要な洞察を提供します.
この研究は,T細胞結合とIgSFの構造的割り当てにおけるCD2の役割の理解を進めています.

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