脊椎動物の頭部の枝状領域のための明確なホックスコード

P Hunt¹, M Gulisano, M Cook

¹MRC Laboratory of Eukaryotic Molecular Genetics, NIMR, Mill Hill, London, UK.

Nature

|October 31, 1991

まとめ

Hox-2遺伝子は,脊椎動物の枝状領域のパターンを示しています. ホックスクラスター内の類似遺伝子は,同一の発現限界を示し,トランク組織とは異なる組み合わせのホックスコードを形成します.

科学分野:

発達生物学発達生物学とは
遺伝学遺伝学とは
進化生物学の進化生物学について

背景:

枝状領域の形成には,ロンボメア,ニューラル・クライスト,枝状弧の複雑な相互作用が伴う.
空間的に制限された発現を持つホックス-2遺伝子は,これらの構造をパターニングし,地域的な多様性を生み出す上で鍵となると考えられています.

研究の目的:

類似のホックス遺伝子の発現限界の違いが,枝状領域の地域多様性に貢献するかどうかを調査する.
ホックス遺伝子のパラログが枝状領域のパターニングの組み合わせコードを提供しているかどうかを判断する.

主な方法:

Hox-2遺伝子発現パターンの分析.
ロンボメア,頭蓋骨,枝状弧における類似遺伝子の発現限界の比較.

主要な成果:

Paralogous Hox遺伝子は,唇のサブファミリーを除いて,枝状領域で同一の発現限界を示しています.
この保存された表現パターンは,枝状領域の組み合わせのホックスコードを示唆しています.

結論:

ブランキアル領域の組み合わせのホックスコードは,組織的には幹部と異なるように見える.
ホックス遺伝子のパラログ発現は,脊椎動物の頭部発達の過程で地域的アイデンティティを確立するために重要である.

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