プレ・ボッツィンガー複合体:哺乳類の呼吸リズムを生成する脳幹領域
J C Smith1, H H Ellenberger, K Ballanyi
1Department of Kinesiology, University of California, Los Angeles 90024-1527.
Science (New York, N.Y.)
|November 1, 1991
まとめ
研究者らは,新生児ラットの脳幹におけるプレ・ボッツィンガー複合体を,呼吸器リズムを生成する上で極めて重要なものとして特定した. この特定の脳領域には,呼吸リズム生成に必要な神経細胞が含まれています.
科学分野:
- 神経科学は神経科学である.
- 呼吸器生理学 呼吸器生理学について
背景:
- 哺乳類の呼吸リズムを生成する神経細胞の正確な位置は,未だに曖昧である.
- 呼吸の神経制御を理解することは,呼吸器官生理学と神経科学にとって根本的なものです.
研究 の 目的:
- 哺乳類における呼吸リズム発生に責任のある特定の脳領域を特定する.
- この特定された領域内のニューロンの性質を調査するために.
主な方法:
- 新生ラットの脳幹のスライスに微細解剖技術を用いた in vitro.
- 呼吸器リズム生成への影響を評価するために,地域性アブレーションを行いました.
- 孤立した領域内のニューロンの電気生理学的性質を記録した.
主要な成果:
- 前ボツィンガー複合体と呼ばれる腹中髄の限られた領域は,リズム生成に不可欠であると特定されました.
- 呼吸器リズムの完全な排除は,前ボツィンガー複合体の除去時に観察されました.
- プレ・ボツィンガー複合体を含む髄膜切片は,呼吸器のような振動を引き起こし,ペースメーカーの性質を持つニューロンは,この複合体内で発見されました.
結論:
- プレ・ボッツィンガー・コンプレックスは,新生児の哺乳類の神経系における呼吸リズム生成の主要な場所として特定されています.
- 呼吸器リズム障害は,前ボツィンガー複合体内に位置する,条件付きで発作するペースメーカーニューロンの集団から生じる可能性が高い.
関連する概念動画
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