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日焼け止めによる紫外線誘発性唇ヘルペスの予防
J F Rooney1, Y Bryson, M L Mannix
1Laboratory of Oral Medicine, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland 20892.
Lancet (London, England)
|December 7, 1991
まとめ
日光曝露は,再発した唇ヘルペス (口唇ヘルペス) を引き起こす可能性があります. 紫外線 (UV) に曝露する前に日焼け止めを塗ることで,臨床試験で,風邪の再活性化を効果的に防ぐことができました.
科学分野:
- 皮膚科 皮膚科について
- ウイルス学 ウイルス学 ウイルス学
- フォトメディシン (光医学)
背景:
- 繰り返し発生するヘルペス・ラビアリスは,しばしば日光曝露に先行する.
- 紫外線 (UV) B放射線は,ヘルペス・シンプレックスウイルス (HSV) の再活性化に起因することが知られている.
研究 の 目的:
- 再発した唇ヘルペスのUV光誘発再活性化を防ぐための日焼け止め剤の有効性を評価する.
- 太陽光によって引き起こされる風邪の発作の管理における日焼け止めの役割を評価する.
主な方法:
- ダブルブラインド,プラセボ対照のクロスオーバー試験が行われました.
- 再発性唇ヘルペス病歴のある38人の患者が2回,紫外線に曝された.
- 紫外線曝露の前に,日焼け止めやプラセボを唇に塗った.
主要な成果:
- ヘルペス・ラビアリスは,プラセボと紫外線被曝後の患者の71%で発症した (平均再発時間は2.9日).
- 紫外線曝露の前に日焼け止めを塗ったとき,発疹病変は発生しませんでした.
- 日焼け止めを塗った後,暴露部位でHSVを放出したのは1人の患者だけでした.
結論:
- 紫外線は,ヘルペス・ラビアリス再活性化のための強力な刺激である.
- 局所的な日焼け止めの適用は,日光に誘発された再発性ヘルペス・ラビアリス感染症の予防に有効であるようです.
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