成人の体重の変化と閉経後の乳がんのリスク

A Heather Eliassen¹, Graham A Colditz, Bernard Rosner

¹Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Mass 02115, USA. heather.eliassen@channing.harvard.edu

JAMA

|July 13, 2006

まとめ

成人期および更年期以降の体重増加は,更年期後の女性の乳がんリスクを増加させます. 更年期後の体重を維持または減量することは,特にホルモン非使用者の場合,乳がんのリスクを下げる可能性があります.

科学分野:

エンドクリノロジーエンドクリノロジー
腫瘍学腫瘍学
エピデミオロジーエピデミオロジー

背景:

内生ホルモンは乳がんの主な原動力である.
肥満は,特に閉経後の女性のホルモンレベルに影響を与え,乳がんの潜在的変更可能な危険因子を示します.

研究の目的:

成人の体重変化 (18歳以降および更年期以降) と,更年期後の女性の乳がんリスクとの関連性を調査する.

主な方法:

看護師の健康調査 (87,143人の閉経後の女性) のデータを利用した前向きなコホート研究.
18歳以降と更年期以降の体重の変化を長期追跡期間 (26歳まで) で評価した.
主なアウトカムとして,侵襲性乳がんの発生率をモニタリングした.

主要な成果:

乳がんリスクの有意な増加は,かなりの体重増加 (18歳以降≥25.0kg,更年期以降≥10.0kg) とともに観察されました.
更年期以降の体重増加は,更年期後のホルモンを使用したことがない女性では,乳がんのリスクとより強い関連性を示しました.
体重減少 (更年期以降≥10.0kg) は,特にホルモン非使用者のリスク低下と関連していました.

結論:

成人の体重増加,特に更年期以降は,更年期後の女性では乳がんのリスクが高まります.
閉経後の体重減少は,乳がんリスクの低下と関連しています.
更年期頃に健康的な体重を維持または達成することは,乳がんのリスクを減らすために推奨されます.

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