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ストレスの多い人生の出来事とグレイヴス病
B Winsa1, H O Adami, R Bergström
1Department of Internal Medicine, Uppsala University, Sweden.
Lancet (London, England)
|December 14, 1991
まとめ
ストレスの多い人生の出来事や,甲状腺疾患の家族歴は,Gravesを発症する重要なリスク要因です.
科学分野:
- エンドクリノロジー エンドクリノロジー
- エピデミオロジー エピデミオロジー
- 心理神経免疫学 心理神経免疫学について
背景:
- ストレスの多い人生の出来事とグレイス病の発症の間の関連性は,以前の研究の限界のために議論されています.
- 以前の研究では,適切なコントロールと診断特異性が欠け,結論を導くことができなかった.
研究 の 目的:
- 人生の出来事,遺伝,社会的支援,そしてグレイス病を発症するリスクとの関連を調査する.
- 潜在的な危険因子を明らかにするために,集団ベースのケース・コントロール研究を実施する.
主な方法:
- 人口ベースの症例対照研究が,約100万人の住民を有する地域で実施されました.
- 新たに診断された208人のグレヴス病患者と372人のマッチングされた対照群は,さまざまなライフスタイルと家族要因に関する郵送されたアンケートに回答した.
- データ分析には,混同要因を調整するための多変量分析が含まれていました.
主要な成果:
- 患者は,診断前の1年間で,より多くのネガティブな人生の出来事を報告しました (OR 6.3).
- 甲状腺疾患の家族歴,特に一,二度の親族の場合は,グレイス病のリスクが増加しました (OR 3.6).
- 離婚 (OR 1.8) とアルコール消費量の低下 (OR 0.4) もリスク増加と関連していました.
結論:
- 人生のネガティブな出来事と遺伝的傾向は,グレイヴス病の重要なリスク要因として特定されています.
- これらの発見は,グレイヴス病の病因における心理社会的および遺伝的要因の役割を支持しています.
- 根本的なメカニズムを解明するためにさらなる研究が必要である.
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