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高コレステロール血症患者の冠動脈微循環における内皮機能障害のL-アルギニンによる矯正
H Drexler1, A M Zeiher, K Meinzer
1Medizinische Klinik III, Universität Freiburg, Germany.
Lancet (London, England)
|December 21, 1991
まとめ
高コレステロールは血管の機能を損ない,血流を低下させます. L-アルギニンサプリメントは,高コレステロール血症患者の正常な血流を成功裏に回復させ,内皮機能不全の潜在的な治療法を示唆しました.
科学分野:
- 心血管医学 心血管医学
- 内皮機能の研究
- メタボリック障害 メタボリック障害
背景:
- 高コレステロール血症は,内皮機能障害と関連しています.
- 内皮機能不全は,窒素酸化物 (NO) の生物利用性の低下から生じ,L-アルギニン欠乏症による可能性がある.
- 高コレステロール血症に対する冠動脈循環の反応については,さらなる調査が必要である.
研究 の 目的:
- L-アルギニンが高コレステロール血症患者の内皮機能不全を逆転させることができるかどうかを調査する.
- L-アルギニンが冠動脈の血流と心臓の動脈機能に与える影響を評価する.
主な方法:
- 研究には,高コレステロール血症患者8名と対照群7名が含まれていました.
- エピカルディアス動脈の直径と冠動脈の血流速度を測定した.
- アセチルコリン (エンドセリウム依存剤) とL-アルギニンを冠内輸液で投与した.
主要な成果:
- 高コレステロール血症の患者は,対照群と比較して,アセチルコリン誘発の冠動脈血流の減少を示した.
- L-アルギニンの注入は,高コレステロール血症患者の冠動脈血流のアセチルコリン誘発の増加を回復させた.
- L-アルギニンは,対照群における冠動脈の血流に影響を与えなかった.
結論:
- 高コレステロール血症は,冠動脈微循環における内皮に依存した膨張を阻害する.
- 短期間のL-アルギニンの投与は,この障害を逆転させることができます.
- L-アルギニンは,高コレステロール血症に起因する内皮機能不全の治療薬としての潜在能力を示しています.
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