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関連する概念動画

RNA Splicing01:32

RNA Splicing

Splicing is the process by which eukaryotic RNA is edited before its translation into protein. The RNA strand transcribed from eukaryotic DNA is called the primary transcript. The primary transcripts that become mRNAs are called precursor messenger RNAs (pre-mRNAs). Eukaryotic pre-mRNA contains alternating sequences of exons and introns. Exons are nucleotide sequences that code for proteins, whereas introns are the non-coding regions. In RNA splicing, introns are removed and exons are bonded...
RNA Splicing01:32

RNA Splicing

Splicing is the process by which eukaryotic RNA is edited before its translation into protein. The RNA strand transcribed from eukaryotic DNA is called the primary transcript. The primary transcripts that become mRNAs are called precursor messenger RNAs (pre-mRNAs). Eukaryotic pre-mRNA contains alternating sequences of exons and introns. Exons are nucleotide sequences that code for proteins, whereas introns are the non-coding regions. In RNA splicing, introns are removed and exons are bonded...
Alternative RNA Splicing02:18

Alternative RNA Splicing

Alternative RNA splicing is the regulated splicing of exons and introns to produce different mature mRNAs from a single pre-mRNA. Unlike in constitutive splicing where a single gene produces a single type of mRNA, alternative splicing allows an organism to produce multiple proteins from a single gene and plays an important role in protein diversity.
There are five types of alternative RNA splicing that vary in the ways the pre-mRNA segments are removed or retained in the mature mRNA. The first...
Exon Recombination02:32

Exon Recombination

The evolution of new genes is critical for speciation. Exon recombination, also known as exon shuffling or domain shuffling, is an important means of new gene formation. It is observed across vertebrates, invertebrates, and in some plants such as potatoes and sunflowers. During exon recombination, exons from the same or different genes recombine and produce new exon-intron combinations, which might evolve into new genes. 
Exon shuffling follows “splice frame rules.” Each exon has three reading...
Pre-mRNA Processing: RNA Splicing01:32

Pre-mRNA Processing: RNA Splicing

Splicing is the process by which eukaryotic RNA is edited before its translation into protein. The RNA strand transcribed from eukaryotic DNA is called the primary transcript. The primary transcripts that become mRNAs are called precursor messenger RNAs (pre-mRNAs). Eukaryotic pre-mRNA contains alternating sequences of exons and introns. Exons are nucleotide sequences that code for proteins, whereas introns are the non-coding regions. In RNA splicing, introns are removed and exons are bonded...
Alternative RNA Splicing02:18

Alternative RNA Splicing

Alternative RNA splicing is the regulated splicing of exons and introns to produce different mature mRNAs from a single pre-mRNA. Unlike in constitutive splicing where a single gene produces a single type of mRNA, alternative splicing allows an organism to produce multiple proteins from a single gene and plays an important role in protein diversity.
There are five types of alternative RNA splicing that vary in the ways the pre-mRNA segments are removed or retained in the mature mRNA. The first...

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関連する実験動画

Updated: Jul 11, 2026

Using RNA-sequencing to Detect Novel Splice Variants Related to Drug Resistance in In Vitro Cancer Models
09:58

Using RNA-sequencing to Detect Novel Splice Variants Related to Drug Resistance in In Vitro Cancer Models

Published on: December 9, 2016

代替スプライシング:グローバル分析からの新しい洞察

Benjamin J Blencowe1

  • 1Banting and Best Department of Medical Research and Department of Molecular and Medical Genetics, Centre for Cellular and Biomolecular Research, Donnelly CCBR Building, University of Toronto, Toronto, ON M5S 3E1, Canada. b.blencowe@utoronto.ca

Cell
|July 15, 2006
PubMed
まとめ

代替スプライシングは,動物における重要なタンパク質の多様性を生み出します. このレビューは,トランスクリプト変異の識別,健康と病気におけるそれらの役割,およびそれらの調整された規制に関する現在の研究をカバーしています.

科学分野:

  • 分子生物学は分子生物学である.
  • ゲノミクスゲノミクスとは
  • プロテオミクス プロテオミクスは,プロテオミクスの

背景:

  • 代替スプライシングは,メタゾーン生物のプロテオミクおよび機能的多様性を生み出すための重要なメカニズムです.
  • 配列とマイクロアレイのデータ分析は,代替スプライシングの重要な役割を強調しています.

研究 の 目的:

  • 代替スプライシングの理解における最近の進展をレビューする.
  • 機能的に関連するトランスクリプト変数のレパートリーを確立する.
  • 病気の生理学と正常生理学におけるこれらの変異の役割を探求する.
  • 細胞および組織特有の機能のための代替スプライシングのグローバルな調整を理解する.

主な方法:

  • シーケンスデータの分析.
  • マイクロアレイデータの分析.
  • 最近の科学文献のレビュー.

主要な成果:

  • 代替スプライシングは,メタゾーンにおけるタンパク質の多様性に大きく貢献しています.
  • 進行中の取り組みは,機能的トランスクリプト変種とその生理学的役割の特定に焦点を当てています.
  • 研究は,代替スプライシングのグローバルな調整を模索しています.

さらに関連する動画

Using the E1A Minigene Tool to Study mRNA Splicing Changes
10:25

Using the E1A Minigene Tool to Study mRNA Splicing Changes

Published on: April 22, 2021

Identification of Alternative Splicing and Polyadenylation in RNA-seq Data
08:35

Identification of Alternative Splicing and Polyadenylation in RNA-seq Data

Published on: June 24, 2021

関連する実験動画

Last Updated: Jul 11, 2026

Using RNA-sequencing to Detect Novel Splice Variants Related to Drug Resistance in In Vitro Cancer Models
09:58

Using RNA-sequencing to Detect Novel Splice Variants Related to Drug Resistance in In Vitro Cancer Models

Published on: December 9, 2016

Using the E1A Minigene Tool to Study mRNA Splicing Changes
10:25

Using the E1A Minigene Tool to Study mRNA Splicing Changes

Published on: April 22, 2021

Identification of Alternative Splicing and Polyadenylation in RNA-seq Data
08:35

Identification of Alternative Splicing and Polyadenylation in RNA-seq Data

Published on: June 24, 2021

結論:

  • 代替スプライシングは,メタゾオの生物学的複雑性にとって極めて重要です.
  • トランスクリプト変種とその規制ネットワークを完全に特徴付けるためにさらなる研究が必要である.