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Updated: Jun 23, 2026

Yeast As a Chassis for Developing Functional Assays to Study Human P53
14:57

Yeast As a Chassis for Developing Functional Assays to Study Human P53

Published on: August 4, 2019

TIGARは,glycolysisとapoptosisのp53-誘導性レギュレータであり,その作用を抑制している

Karim Bensaad1, Atsushi Tsuruta, Mary A Selak

  • 1The Beatson Institute for Cancer Research, Switchback Road, Glasgow G61 1BD, UK.

Cell
|July 15, 2006
PubMed
まとめ

腫瘍抑制剤p53は,TIGAR遺伝子を介して細胞死を調節する. TIGARは活性酸素種 (ROS) と糖分解を減少させ,p53誘発のアポトーシスとゲノム損傷から細胞を保護します.

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