Jove
Visualize
お問い合わせ
JoVE
x logofacebook logolinkedin logoyoutube logo
JoVEについて
概要リーダーシップブログJoVEヘルプセンター
著者向け
出版プロセス編集委員会範囲と方針査読よくある質問投稿
図書館員向け
推薦の声購読アクセスリソース図書館諮問委員会よくある質問
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experimentsアーカイブ
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教員リソースセンター教員サイト
利用規約
プライバシーポリシー
ポリシー

関連する概念動画

Antigen Processing Pathways01:31

Antigen Processing Pathways

3.0K
MHC molecules are key players in the immune response, enabling T cells to recognize and respond to specific antigens. They are present on the surface of all nucleated cells in the body and are instrumental in presenting antigens to T cells and activating them. T cells recognize the MHC-antigen complex and initiate an immune response. MHC class I and MHC class II are two main types of MHC molecules, each associated with a distinct antigen processing pathway.
MHC Class I: Presenting Endogenous...
3.0K
Immune Surveillance by NK Cells and Phagocytes01:25

Immune Surveillance by NK Cells and Phagocytes

9.5K
Immune surveillance is an integral part of the innate immune system, involving the continuous monitoring of peripheral tissues to detect and respond to pathogens, infected cells, or cancerous cells. This surveillance is conducted primarily by natural killer (NK) cells and phagocytes, which employ distinct but complementary mechanisms to identify and eliminate threats.
Natural Killer Cells: The Fast Responders
NK cells are large granular lymphocytes found in the blood and lymphatic system. These...
9.5K
Antigens Involved in Adaptive Immunity01:26

Antigens Involved in Adaptive Immunity

1.8K
An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and...
1.8K
T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

17.3K
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
17.3K
Antigen Presenting Cells01:22

Antigen Presenting Cells

4.3K
The immune system is a complex network of cells and molecules that protects the body from foreign invaders. T cells, a type of white blood cell, play a crucial role in this process. They recognize and attack foreign substances, such as pathogens, that enter the body.
T cells require the help of antigen-presenting cells (APCs), which process foreign antigens into smaller fragments that can be recognized by T cells. These APCs are highly specialized cells that efficiently internalize antigens...
4.3K
Phagocytosis of Apoptotic Cells01:17

Phagocytosis of Apoptotic Cells

5.6K
Cells undergoing apoptosis form apoptotic bodies that must be removed immediately to prevent inflammation, autoimmune diseases, and necrosis. Phagocytosis is carried out by professional phagocytes such as macrophages or  immature dendritic cells. Non-professional phagocytes such as  epithelial cells and fibroblasts also take part in this process; however, they are not as effective as professional phagocytes. 
Normal cells contain receptors that prevent them from being recognized...
5.6K

こちらも読む

関連記事

共著者、ジャーナル、引用グラフによってこの研究に関連する記事。

並び替え
Same author

Antigen uptake: Breaking convention.

Trends in immunology·2026
Same author

Mechanosensing in immune cells: Implications for migration and beyond.

Current opinion in cell biology·2026
Same author

CD133 Shapes Extracellular Vesicle Cargo and Angiogenic Function in Basal-Like Triple-Negative Breast Cancer.

Journal of extracellular vesicles·2026
Same author

Macrophages restrict tumor immune infiltration by controlling collagen topography.

Science immunology·2026
Same author

Insights into lysosome-related organelle biogenesis: melanosome as a model organelle.

Frontiers in cell and developmental biology·2026
Same author

Influence of the Cholinergic System on the Pathogenesis of Glioblastoma: Impact of the Neutrophil Granulocytes.

International journal of molecular sciences·2026

関連する実験動画

Updated: Mar 29, 2026

Purification of the Membrane Compartment for Endoplasmic Reticulum-associated Degradation of Exogenous Antigens in Cross-presentation
12:48

Purification of the Membrane Compartment for Endoplasmic Reticulum-associated Degradation of Exogenous Antigens in Cross-presentation

Published on: August 21, 2017

8.7K

NOX2はファゴソームのpHを制御し, dendritic細胞によるクロスプレゼンテーション中の抗原処理を調節します.

Ariel Savina1, Carolina Jancic, Stephanie Hugues

  • 1Institut Curie, INSERM U653, Immunité et Cancer, 26 rue d'Ulm, 75248 Paris, Cedex 05, France.

Cell
|July 15, 2006
PubMed
まとめ

デンドリット細胞 (DCs) はNADPH酸化酵素NOX2を使用して,ファゴソームのpHを制御し,抗原破壊を防止します. これは,適応免疫のための適切なT細胞認識を保証します.

さらに関連する動画

Measuring Phagosome pH by Ratiometric Fluorescence Microscopy
14:39

Measuring Phagosome pH by Ratiometric Fluorescence Microscopy

Published on: December 7, 2015

14.5K
Study of Phagolysosome Biogenesis in Live Macrophages
08:06

Study of Phagolysosome Biogenesis in Live Macrophages

Published on: March 11, 2014

14.9K

関連する実験動画

Last Updated: Mar 29, 2026

Purification of the Membrane Compartment for Endoplasmic Reticulum-associated Degradation of Exogenous Antigens in Cross-presentation
12:48

Purification of the Membrane Compartment for Endoplasmic Reticulum-associated Degradation of Exogenous Antigens in Cross-presentation

Published on: August 21, 2017

8.7K
Measuring Phagosome pH by Ratiometric Fluorescence Microscopy
14:39

Measuring Phagosome pH by Ratiometric Fluorescence Microscopy

Published on: December 7, 2015

14.5K
Study of Phagolysosome Biogenesis in Live Macrophages
08:06

Study of Phagolysosome Biogenesis in Live Macrophages

Published on: March 11, 2014

14.9K

科学分野:

  • 免疫学 免疫学とは
  • 細胞生物学 細胞生物学

背景:

  • 適応性細胞毒性免疫応答は,交叉プレゼンテーションを通じて, dendritic cells (DCs) から CD8+ T細胞への抗原プレゼンテーションに依存しています.
  • 制御された抗原の分解は極めて重要です;酸性ファゴソームの過剰な分解は,T細胞認識に必要なペプチドを破壊することができます.

研究 の 目的:

  • アンチゲン処理を微調整するDCの特殊なファゴサイト経路を調査する.
  • 抗原プレゼンテーション中のファゴソーム環境の調節におけるNADPH酸化酵素NOX2の役割を明らかにする.

主な方法:

  • DCsの初期のファゴソームにNADPH酸化酵素NOX2の徴募を研究しました.
  • NOX2がファゴソームのpHと活性酸素種生成に与える影響を評価した.
  • ワイルド型DCとNOX2欠乏型DCの抗原分解とクロスプレゼンテーション効率の比較.

主要な成果:

  • NOX2は初期のファゴソームに局所化し,持続的な低レベルの活性酸素種生産を媒介する.
  • このNOX2の活動により,ファゴソームのがアルカリ化します.
  • NOX2が欠けているDCは,ファゴソーム酸性化と抗原分解が増加し,クロスプレゼンテーションが損なわれます.

結論:

  • NOX2は,DCsで制御されたファゴソーム環境を維持するために重要であり,クロスプレゼンテーションのための抗原処理を最適化します.
  • NOX2により,DCは,病原体を殺す細胞ではなく,抗原を処理する特殊なファゴサイトとして機能することができます.