関連する実験動画

Updated: Jun 14, 2026

Modified Yeast-Two-Hybrid System to Identify Proteins Interacting with the Growth Factor Progranulin
07:56

Modified Yeast-Two-Hybrid System to Identify Proteins Interacting with the Growth Factor Progranulin

Published on: January 17, 2012

プログランウリンのゼロ変異は,染色体17q21と関連したウビキチン陽性フロントテンポラル認知症を引き起こす

Marc Cruts1, Ilse Gijselinck, Julie van der Zee

  • 1Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, Flanders Interuniversity Institute for Biotechnology, Universiteitsplein 1, BE-2610 Antwerpen, Belgium.

Nature
|July 25, 2006
PubMed
まとめ

プログランウリン (PGRN) 遺伝子の変異は,PGRNレベルを低下させ,神経変性を引き起こすことにより,前頭葉門性認知症 (FTDU-17) を引き起こします. PGRN変異は,家族性FTDでは,MAPT変異よりも一般的です.

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