Jove
Visualize
お問い合わせ
JoVE
x logofacebook logolinkedin logoyoutube logo
JoVEについて
概要リーダーシップブログJoVEヘルプセンター
著者向け
出版プロセス編集委員会範囲と方針査読よくある質問投稿
図書館員向け
推薦の声購読アクセスリソース図書館諮問委員会よくある質問
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experimentsアーカイブ
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教員リソースセンター教員サイト
利用規約
プライバシーポリシー
ポリシー

関連する概念動画

Experimental RNAi02:15

Experimental RNAi

8.3K
RNA interference (RNAi) is a cellular mechanism that inhibits gene expression by suppressing its transcription or activating the RNA degradation process. The mechanism was discovered by Andrew Fire and Craig Mello in 1998 in plants. Today, it is observed in almost all eukaryotes, including protozoa, flies, nematodes, insects, parasites, and mammals. This precise cellular mechanism of gene silencing has been developed into a technique that provides an efficient way to identify and determine the...
8.3K
siRNA - Small Interfering RNAs02:30

siRNA - Small Interfering RNAs

19.0K
Small interfering RNAs, or siRNAs, are short regulatory RNA molecules that can silence genes post-transcriptionally, as well as the transcriptional level in some cases. siRNAs are important for protecting cells against viral infections and silencing transposable genetic elements.
In the cytoplasm, siRNA is processed from a double-stranded RNA, which comes from either endogenous DNA transcription or exogenous sources like a virus. This double-stranded RNA is then cleaved by the...
19.0K
Small interfering RNAs (siRNA)02:30

Small interfering RNAs (siRNA)

5.3K
No description available
5.3K
RNA Interference01:23

RNA Interference

28.6K
RNA interference (RNAi) is a process in which a small non-coding RNA molecule blocks the post-transcriptional expression of a gene by binding to its messenger RNA (mRNA) and preventing the protein from being translated.
This process occurs naturally in cells, often through the activity of genomically-encoded microRNAs. Researchers can take advantage of this mechanism by introducing synthetic RNAs to deactivate specific genes for research or therapeutic purposes. For example, RNAi could be used...
28.6K

こちらも読む

関連記事

共著者、ジャーナル、引用グラフによってこの研究に関連する記事。

並び替え
Same author

Identification of cross-stage, cross-species malaria CD8<sup>+</sup> T cell antigens.

Nature·2026
Same author

Distal enhancer-insulator module of GDF6 is essential for cochlear formation.

JCI insight·2026
Same author

A cell-death protein has an unexpected role in intestinal repair.

Nature·2026
Same author

Disrupted lipid homeostasis as a pathogenic mechanism in ABCA7-associated Alzheimer's disease risk.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same author

Enhanced Hi-C Capture Analysis reveals complex regulatory architecture at the <i>PICALM_EED</i> locus for Alzheimer's disease.

bioRxiv : the preprint server for biology·2026
Same author

Pyroptosis: Turning Up the Heat on Cancer.

Annual review of immunology·2026
Same journal

A viral ORFeome library for systems-level genetic dissection of host-pathogen interactions.

Cell·2026
Same journal

Co-option of lysosomal machinery shapes the evolution of the intracellular photosymbiosis supporting coral reefs.

Cell·2026
Same journal

LEF1 and niche factors determine T cell stemness across chronic diseases.

Cell·2026
Same journal

Recurrent patterns of TOP1-mediated neuronal genomic damage shared by major neurodegenerative disorders.

Cell·2026
Same journal

Four-dimensional molecular mapping from a spatial snapshot reveals the dynamics of hair follicle organogenesis.

Cell·2026
Same journal

Whole-cell particle-based digital twin simulations from 4D lattice light-sheet microscopy data.

Cell·2026
関連記事をすべて見る

関連する実験動画

Updated: Mar 30, 2026

Rearing and Double-stranded RNA-mediated Gene Knockdown in the Hide Beetle, Dermestes maculatus
09:57

Rearing and Double-stranded RNA-mediated Gene Knockdown in the Hide Beetle, Dermestes maculatus

Published on: December 28, 2016

11.4K

siRNAsで病気を撲滅する

Derek M Dykxhoorn1, Judy Lieberman

  • 1CBR Institute for Biomedical Research and Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA.

Cell
|July 29, 2006
PubMed
まとめ
この要約は機械生成です。

小型の干渉RNA (siRNAs) は,疾患に関連する遺伝子を沈黙させることで治療的可能性を秘めています. このアプローチであるRNA干渉療法 (RNAi) は,課題に直面しているが,有望な治療機会を提示している.

さらに関連する動画

Chitosan/Interfering RNA Nanoparticle Mediated Gene Silencing in Disease Vector Mosquito Larvae
08:36

Chitosan/Interfering RNA Nanoparticle Mediated Gene Silencing in Disease Vector Mosquito Larvae

Published on: March 25, 2015

15.2K
Large-scale Gene Knockdown in C. elegans Using dsRNA Feeding Libraries to Generate Robust Loss-of-function Phenotypes
18:38

Large-scale Gene Knockdown in C. elegans Using dsRNA Feeding Libraries to Generate Robust Loss-of-function Phenotypes

Published on: September 26, 2013

12.5K

関連する実験動画

Last Updated: Mar 30, 2026

Rearing and Double-stranded RNA-mediated Gene Knockdown in the Hide Beetle, Dermestes maculatus
09:57

Rearing and Double-stranded RNA-mediated Gene Knockdown in the Hide Beetle, Dermestes maculatus

Published on: December 28, 2016

11.4K
Chitosan/Interfering RNA Nanoparticle Mediated Gene Silencing in Disease Vector Mosquito Larvae
08:36

Chitosan/Interfering RNA Nanoparticle Mediated Gene Silencing in Disease Vector Mosquito Larvae

Published on: March 25, 2015

15.2K
Large-scale Gene Knockdown in C. elegans Using dsRNA Feeding Libraries to Generate Robust Loss-of-function Phenotypes
18:38

Large-scale Gene Knockdown in C. elegans Using dsRNA Feeding Libraries to Generate Robust Loss-of-function Phenotypes

Published on: September 26, 2013

12.5K

科学分野:

  • バイオケミストリー バイオケミストリー
  • 分子生物学は分子生物学である.
  • 遺伝学 遺伝学とは

背景:

  • 遺伝子サイレンシングは,生物学的プロセスにおける重要なメカニズムです.
  • 小型の干渉RNA (siRNAs) は,RNA干渉 (RNAi) の重要な分子である.
  • 遺伝子発現の調節不全は,多くの疾患に起因しています.

研究 の 目的:

  • siRNAsを用いたRNA干渉 (RNAi) の治療の可能性を調査する.
  • siRNAベースの治療法の開発における機会と課題を特定する.
  • RNAiの治療応用における障害を克服するための戦略を提案する.

主な方法:

  • RNA干渉 (RNAi) とsiRNA技術に関する現在の文献のレビュー.
  • siRNA療法に関する臨床前および臨床研究の分析.
  • siRNAsに関連する伝達システムとオフターゲットの効果の検討.

主要な成果:

  • siRNAは,さまざまな疾患モデルにおいて,標的遺伝子のノックダウンに重要な潜在能力を示しています.
  • siRNAを標的組織に届けることは,依然として大きな障害となっています.
  • 標的外効果と免疫反応は,安全な治療用途のために慎重に管理する必要があります.

結論:

  • RNA干渉 (RNAi) は,遺伝的疾患やその他の疾患の治療に大きな希望を持っています.
  • 配達と安全性の課題を克服することは,siRNA治療法の臨床成功にとって不可欠です.
  • siRNAの設計と配送の最適化に関するさらなる研究は,その完全な治療的可能性を実現するために不可欠です.