Jove
Visualize
お問い合わせ
JoVE
x logofacebook logolinkedin logoyoutube logo
JoVEについて
概要リーダーシップブログJoVEヘルプセンター
著者向け
出版プロセス編集委員会範囲と方針査読よくある質問投稿
図書館員向け
推薦の声購読アクセスリソース図書館諮問委員会よくある質問
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experimentsアーカイブ
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教員リソースセンター教員サイト
利用規約
プライバシーポリシー
ポリシー

関連する概念動画

Translation01:31

Translation

Lesson: Translation
Translation is the process of synthesizing proteins from the genetic information carried by messenger RNA (mRNA). Following transcription, it constitutes the final step in the expression of genes. This process is carried out by ribosomes, complexes of protein and specialized RNA molecules. Ribosomes, transfer RNA (tRNA), and other proteins produce a chain of amino acids—the polypeptide—as the end product of translation.
Translation Produces the Building Blocks of Life
Translation01:31

Translation

Lesson: Translation
Translation is the process of synthesizing proteins from the genetic information carried by messenger RNA (mRNA). Following transcription, it constitutes the final step in the expression of genes. This process is carried out by ribosomes, complexes of protein and specialized RNA molecules. Ribosomes, transfer RNA (tRNA), and other proteins produce a chain of amino acids—the polypeptide—as the end product of translation.
Translation Produces the Building Blocks of Life
Disorders of the Nervous Tissue01:28

Disorders of the Nervous Tissue

Nervous tissue is a vital component of the human body's communication system, enabling us to perceive and respond to stimuli. However, like all other tissues, it is vulnerable to disorders and diseases that can significantly impact our neurological functioning.
Homeostatic Imbalances:
Alzheimer's disease manifests as a gradual decline in memory and cognitive abilities, attributed to the buildup of amyloid plaques and neurofibrillary tangles in the brain.
Parkinson's disease arises from the...
Alzheimer's Disease: Treatment01:22

Alzheimer's Disease: Treatment

Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...
Alzheimer Disease l: Introduction01:29

Alzheimer Disease l: Introduction

Alzheimer disease is a chronic, progressive, and irreversible neurodegenerative disorder and the most common cause of dementia in older adults. It leads to gradual neuronal loss, causing cognitive decline, behavioral changes, and loss of functional independence.Risk Factors and EtiologyThe disease is multifactorial. Age is the strongest risk factor, with prevalence doubling every 5 years after age 65. Genetic factors include mutations in genes such as APP, PSEN1, and PSEN2, which are associated...
Huntington Disease l: Introduction01:21

Huntington Disease l: Introduction

Huntington disease or HD is a progressive, fatal neurodegenerative disorder inherited in an autosomal dominant pattern.PathophysiologyIt is caused by expansion of the CAG trinucleotide repeat in the HTT gene on chromosome 4 (4p16.3), producing an abnormal huntingtin protein with an expanded polyglutamine tract. This misfolded protein disrupts cellular function, leading to neuronal death. Normal alleles have ≤26 repeats, 27–35 are intermediate (risk of expansion), 36–39 show reduced penetrance,...

こちらも読む

関連記事

共著者、ジャーナル、引用グラフによってこの研究に関連する記事。

並び替え
Same author

APLP1 as a cerebrospinal fluid biomarker for γ-secretase modulator treatment.

Alzheimer's research & therapy·2015
Same author

Cerebrospinal fluid markers of central nervous system injury in decompression illness - a case-controlled pilot study.

Diving and hyperbaric medicine·2015
Same author

Total-tau and neurofilament light in CSF reflect spinal cord ischaemia after endovascular aortic repair.

Neurochemistry international·2015
Same author

Genome-wide analysis of genetic correlation in dementia with Lewy bodies, Parkinson's and Alzheimer's diseases.

Neurobiology of aging·2015
Same author

Neuromodulation of fast-spiking and non-fast-spiking hippocampal CA1 interneurons by human cerebrospinal fluid.

The Journal of physiology·2015
Same author

Identification of novel CSF biomarkers for neurodegeneration and their validation by a high-throughput multiplexed targeted proteomic assay.

Molecular neurodegeneration·2015

関連する実験動画

Updated: Jul 6, 2026

ALS - Motor Neuron Disease: Mechanism and Development of New Therapies
15:48

ALS - Motor Neuron Disease: Mechanism and Development of New Therapies

Published on: July 29, 2007

アルツハイマー病 (Alzheimer's disease) とは,アルツハイマー病 (Alzheimer's disease) とは,アルツハイマー病 (Alzheimer's

Kaj Blennow1, Mony J de Leon, Henrik Zetterberg

  • 1Clinical Neurochemistry Laboratory, Department of Neuroscience and Physiology, Sahlgren's University Hospital, Mölndal, Sweden. kaj.blennow@neuro.gu.se

Lancet (London, England)
|August 1, 2006
PubMed
まとめ
この要約は機械生成です。

認知症の一般的なアルツハイマー病には,アミロイドβプラークとタウ・タングルが含まれています. その複雑な原因は,特に散発的な形態では,老化,遺伝,環境要因を含んでおり,効果的な治療法を見つけるためにさらなる研究が必要です.

さらに関連する動画

Genetic Analysis of Hereditary Transthyretin Ala97Ser Related Amyloidosis
06:33

Genetic Analysis of Hereditary Transthyretin Ala97Ser Related Amyloidosis

Published on: June 9, 2018

Wild-type Blocking PCR Combined with Sanger Sequencing for Detection of Low-frequency Somatic Mutation
07:17

Wild-type Blocking PCR Combined with Sanger Sequencing for Detection of Low-frequency Somatic Mutation

Published on: August 23, 2024

関連する実験動画

Last Updated: Jul 6, 2026

ALS - Motor Neuron Disease: Mechanism and Development of New Therapies
15:48

ALS - Motor Neuron Disease: Mechanism and Development of New Therapies

Published on: July 29, 2007

Genetic Analysis of Hereditary Transthyretin Ala97Ser Related Amyloidosis
06:33

Genetic Analysis of Hereditary Transthyretin Ala97Ser Related Amyloidosis

Published on: June 9, 2018

Wild-type Blocking PCR Combined with Sanger Sequencing for Detection of Low-frequency Somatic Mutation
07:17

Wild-type Blocking PCR Combined with Sanger Sequencing for Detection of Low-frequency Somatic Mutation

Published on: August 23, 2024

科学分野:

  • 神経学 神経学とは
  • 分子生物学は分子生物学である.
  • 遺伝学 遺伝学とは

背景:

  • アルツハイマー病 (AD) は認知症の主要な原因です.
  • 主な病理学的特徴には,アミロイドベータ (Abeta) プラークと高酸化タウの絡みがある.
  • アルツハイマー病の病原性を理解する過程は進んでおり,重要な複雑性が明らかになっています.

研究 の 目的:

  • アルツハイマー病の疫学,遺伝学,病原性,診断,治療をレビューする.
  • AD研究における最近の進展と進行中の論争を強調する.
  • アルツハイマー病の家族型と散発型を区別する.

主な方法:

  • アルツハイマー病に関する既存の文献のレビュー.
  • アベタとタウを含む分子病原性の分析.
  • 散発的なADの遺伝的および環境的リスク要因の検討.

主要な成果:

  • ファミリアルツハイマー病は稀であり,早期発症であり,アベタ代謝に影響するAPPおよびプレセニリン遺伝子変異と関連しています.
  • 散発的なADは一般的なもので,老化,遺伝,環境の相互作用に起因する原因は不明である.
  • 散発的なADの異質性は,理解と治療の開発を複雑にします.

結論:

  • アルツハイマー病の病原性は複雑で,遺伝的要因と環境的要因の両方が関与しています.
  • 散発性アルツハイマー病の原因を解明し,ターゲットを絞った治療法を開発するために,さらなる研究が不可欠です.
  • 分子機構から危険因子まで,ADの包括的な理解は,臨床的進歩にとって不可欠です.