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Updated: Jun 26, 2026

Enhancement of Apoptotic and Autophagic Induction by a Novel Synthetic C-1 Analogue of 7-deoxypancratistatin in Human Breast Adenocarcinoma and Neuroblastoma Cells with Tamoxifen
19:44

Enhancement of Apoptotic and Autophagic Induction by a Novel Synthetic C-1 Analogue of 7-deoxypancratistatin in Human Breast Adenocarcinoma and Neuroblastoma Cells with Tamoxifen

Published on: May 30, 2012

CPI-17による腫瘍性変異は,メルリンリンホスファタゼの抑制による

Hongchuan Jin1, Tobias Sperka, Peter Herrlich

  • 1Leibniz Institute of Age Research-Fritz-Lipmann-Institute, Beutenbergstrasse 11, 07745 Jena, Germany.

Nature
|August 4, 2006
PubMed
まとめ

ミオシン・フォスファターゼ (MYPT-1-PP1delta) は,デフォスフォリレーションによって腫瘍抑制物質マーリンを活性化します. その阻害剤であるCPI-17は,このマーリン経路を妨害することによって癌を促進し,新しい腫瘍抑制カスケードを強調します.

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