アディポネクチンと冠動脈疾患:前向きな研究とメタ解析
Naveed Sattar1, Goya Wannamethee, Nadeem Sarwar
1University Department of Vascular Biochemistry, Glasgow, Scotland. nsattar@clinmed.gla.ac.uk
Circulation
|August 9, 2006
まとめ
アディポネクチンのレベルは,冠動脈疾患 (CHD) のリスクと弱い関連を示しています. この前向きな研究とメタアナリシスでは,アディポネクチンと心臓病との間に有意な関連性が見つかりませんでしたが,2型糖尿病との強い関連性があります.
科学分野:
- 心血管科学 心血管科学
- メタボリック・ヘルス メタボリック・ヘルス
- バイオマーカーの研究
背景:
- アディポネクチンと冠動脈疾患 (CHD) のリスクとの関連は完全に理解されていません.
- 既存の研究は,心臓血管疾患におけるアディポネクチンの役割に関する矛盾する証拠を提示しています.
研究 の 目的:
- 循環中のアディポネクチン濃度と,心血管疾患を発症するリスクとの関連を調査する.
- メタアナリシスにおける既存の研究と新しい見通しデータを統合する.
主な方法:
- 5661人の男性 (40-59歳) の前向きなコホートの中で,ネストされた症例対照研究が行われました.
- ベースラインの血清アディポネクチンのレベルは,心血管疾患のイベントを患った589人の男性と1231人の対照群で測定されました.
- 現在の研究を含む7つの前向きな研究のメタ分析を行い,CHDリスクの推定をまとめました.
主要な成果:
- アディポネクチンのレベルは,HDLコレステロールと正に相関し,C反応性タンパク質とBMIと逆に相関した.
- CHD症例と対照群の間で,アディポネクチンの中央値の有意な差は見つかりませんでした.
- 1318件のCHD症例のメタ解析は,アディポネクチンレベルを超えてCHDの非有意な確率比0.84 (95%CI,0.70から1.01) を示した.
結論:
- アディポネクチン濃度と心血管疾患のリスクとの関連は,II型糖尿病との強い関連とは対照的に,適度なようです.
- 心血管疾患の病原性におけるアディポネクチンの正確な役割を明らかにするために,さらなる研究が必要である.
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