サルモネラ・リポポリサッカリドは,反応性関節炎患者からのシノヴィアル細胞に含まれています
K Granfors1, S Jalkanen, A A Lindberg
1Department of Medical Microbiology, Turku University, Finland.
Lancet (London, England)
|March 24, 1990
まとめ
サルモネラ抗原,特にリポポリサッカリド (LPS) は,反応性関節炎患者のシノビア細胞で検出されました. この発見は,反応性関節炎における関節炎の病原性における細菌性LPSの役割を強調しています.
科学分野:
- 微生物学 微生物学とは
- 免疫学 免疫学とは
- レウマトロジーの病理学
背景:
- 反応性関節炎は,細菌感染後に発生する炎症性関節炎の一種です.
- サルモネラ菌種は,反応性関節炎の一般的な原因です.
- サルモネラ菌感染が関節炎を誘発する正確なメカニズムは,完全に理解されていません.
研究 の 目的:
- 反応性関節炎患者のシナヴィアル細胞および組織におけるサルモネラ抗原の存在と位置を調べる.
- 感染した関節にサルモネラ・リポポリサッカリド (LPS) が存在するかどうかを判断します.
主な方法:
- サルモネラ菌に対するアンチセラおよびモノクローナル抗体を使用して,シノビア液の細胞および組織の免疫光染色.
- シノビア組織染色のためのアビジン-バイオチン-過酸化酵素複合法.
- サルモネラ LPS.を検出するために,シノビア細胞のウェスタン・ブラッティング.
主要な成果:
- サルモネラ抗原は,反応性関節炎の患者9人中8人のシノヴィアル液細胞で,免疫光検査で検出されました.
- 1人の患者のシノヴィアル組織は,サルモネラ抗原の陽性染色を示した.
- ウェスタン・ブラッティングでは,8人の患者のうち4人のシノビア細胞にサルモネラLPSの存在が確認されました.
- 他のリウマチ病を患っている患者のコントロールサンプルでは,一貫して陰性でした.
結論:
- サルモネラ菌からの細菌性リポポリサッカリド (LPS) は,反応性関節炎患者の胞細胞に存在します.
- 関節における細菌性LPSの検出は,反応性関節炎の病原性における重要かつ一般的な特徴である.
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