南アフリカの黒人のC型肝炎ウイルス抗体で,肝細胞癌を発症しています
M C Kew1, M Houghton, Q L Choo
1Department of Medicine, University of the Witwatersrand, Johannesburg, South Africa.
Lancet (London, England)
|April 14, 1990
まとめ
C型肝炎ウイルス (HCV) は南アフリカの黒人の肝がんと関連しているが,B型肝炎ウイルス (HBV) はより一般的です. この研究では,肝細胞癌患者の両方のウイルス感染症の罹患率を調査しました.
科学分野:
- 肝臓病理学 肝臓病理学
- 感染症 感染症は感染症です.
- 腫瘍学 腫瘍学
背景:
- 肝細胞癌 (HCC) は,世界的な健康上の重大な懸念事項である.
- ウイルス性肝炎,特にB型肝炎ウイルス (HBV) とC型肝炎ウイルス (HCV) は,HCCの主要な危険因子です.
- HCCにおけるHBVとHCVの病因学的役割を理解することは,流行地域における公衆衛生の介入にとって極めて重要です.
研究 の 目的:
- 南アフリカの黒人におけるC型肝炎ウイルス (HCV) と肝細胞癌 (HCC) の関連性を調査する.
- HCC患者における現在のおよび過去のB型肝炎ウイルス (HBV) 感染の流行を決定する.
- HCV陽性のHCC患者の疫学的特徴を比較する.
主な方法:
- 380人の南アフリカ系黒人HCC患者と152人の対照群を対象としたケース・コントロール研究.
- HCVに対する抗体と,現在の/過去のHBV感染のマーカーの血清検査.
- 性別,都市/農村での居住,および年齢を含む人口統計データの分析.
主要な成果:
- HCV抗体は,110人のHCC患者と1人の対照群で検出されました.
- 現在のHBV感染または過去のHBV感染の証拠は,それぞれ184人および122人のHCC患者で発見されました.
- HCV陽性患者は,女性,都市部住民,および高齢者の高い罹患率を示した; しかし,HBV感染は,全体的にHCC患者のより大きな割合で存在した.
結論:
- C型肝炎ウイルス (HCV) は,南アフリカの黒人の肝細胞癌 (HCC) と関連しています.
- B型肝炎ウイルス (HBV) は,この集団のHCC患者の中で流行する感染症です.
- 同感染と異なる疫学的プロファイルは,ウイルス性肝炎とHCCの発症の複雑な相互作用を強調しています.
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