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Updated: May 10, 2026

Systems Biology of Metabolic Regulation by Estrogen Receptor Signaling in Breast Cancer
10:36

Systems Biology of Metabolic Regulation by Estrogen Receptor Signaling in Breast Cancer

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核受容体発現の解剖学的プロファイリングは,階層的な転写ネットワークを明らかにします

Angie L Bookout1, Yangsik Jeong, Michael Downes

  • 1Department of Pharmacology, Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, 6001 Forest Park Road, Dallas, 75390, USA.

Cell
|August 23, 2006
PubMed
まとめ

核受容体 (NRs) は,生命の重要なプロセスを調節する. この研究では,39匹のマウス組織にわたるNR mRNA発現をマッピングし,生殖,発達,代謝を制御するネットワークを明らかにしました.

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Real-time Analysis of Transcription Factor Binding, Transcription, Translation, and Turnover to Display Global Events During Cellular Activation

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Mapping the Structure-Function Relationships of Disordered Oncogenic Transcription Factors Using Transcriptomic Analysis09:58

Mapping the Structure-Function Relationships of Disordered Oncogenic Transcription Factors Using Transcriptomic Analysis

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Co-activators and Co-repressors02:04

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Nuclear receptors, or NRs, are unique transcription factors that regulate gene transcription and affect the cellular pathways involved in reproduction, development, or metabolism. Their ability to be stimulated by small lipophilic ligands and control vital cellular processes makes them ideal drug targets. Nearly 10-15% of currently prescribed drugs target these receptors.
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