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Updated: Jul 20, 2026

Quantitative Detection of DNA-Protein Crosslinks and Their Post-Translational Modifications
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ATMは,DNA損傷後のE3ユビキチンリガゼCOP1の自己分解を誘発する

David Dornan1, Harumi Shimizu, Angie Mah

  • 1Department of Physiological Chemistry, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.

Science (New York, N.Y.)
|August 26, 2006
PubMed
まとめ

アタクシア・テランジエクタシア変異 (ATM) タンパク質キナーゼは,DNA損傷後のCOP1-p53軸を調節する. 387) のCOP1のATMリン酸化によりCOP1-p53結合が妨げられ,p53とその腫瘍抑制機能が安定する.

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