関連する実験動画

Updated: Jul 18, 2026

Improved Preparation and Preservation of Hippocampal Mouse Slices for a Very Stable and Reproducible Recording of Long-term Potentiation
09:39

Improved Preparation and Preservation of Hippocampal Mouse Slices for a Very Stable and Reproducible Recording of Long-term Potentiation

Published on: June 26, 2013

LTPのメンテナンスメカニズムによる空間情報の保存

Eva Pastalkova1, Peter Serrano, Deana Pinkhasova

  • 1Departments of Physiology, Pharmacology, and Neurology, Robert F. Furchgott Center for Neural and Behavioral Science, SUNY Downstate Medical Center, 450 Clarkson Avenue, Brooklyn, NY 11203, USA.

Science (New York, N.Y.)
|August 26, 2006
PubMed
まとめ

タンパク質キナーゼMzeta (PKMz) は,長期増強 (LTP) と空間記憶を維持する. ネズミのPKMzを阻害すると,LTPが逆転し,空間情報の持続的な喪失を引き起こし,記憶記憶におけるPKMzの役割が確認されました.

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Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre- and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
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Long-term Potentiation

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