施設内のアルツハイマー病患者の発熱の結果に対する抗生物質治療の効果
K J Fabiszewski1, B Volicer, L Volicer
1Geriatric Research, Education & Clinical Center, E. N. Rogers Memorial Veterans Hospital, Bedford, Mass. 01730.
JAMA
|June 20, 1990
まとめ
アルツハイマー病患者の熱に対する抗生物質治療は,進行した症例の結果に影響を与えませんでした. しかし,より重度の影響が少ない患者は,抗生物質の介入により生存率が向上したことを示しました.
科学分野:
- ゲリアトリクス ゲリアトリクス
- 神経学 神経学とは
- 感染症 感染症は感染症です.
背景:
- アルツハイマー病 (AD) の患者はしばしば発熱のエピソードを経験します.
- 施設内のAD患者における熱の発症に対する抗生物質治療の影響については,説明が必要である.
研究 の 目的:
- 施設内のアルツハイマー病患者の発熱に関する抗生物質治療と緩和ケアとの効果を将来的に評価する.
主な方法:
- 34ヶ月の前向きな研究では,抗生物質グループ (診断作業と抗生物質) と緩和グループ (慰安措置のみ) を比較しました.
- 生存分析は,疾患の重度に基づいてグループ間のアウトカムを比較するために使用されました.
主要な成果:
- 発熱の発生率は両方のグループで類似していました.
- 重度の影響を受けた患者のグループ間では生存率の違いは観察されなかった.
- 軽度の影響を受けた患者は,緩和療法群と比較して,抗生物質群でより高い生存率を示した.
結論:
- 発熱に対する抗生物質治療は,進行したアルツハイマー病の治療結果を変えることはありません.
- 抗生物質は,発熱を経験するアルツハイマー病の重症でない患者の生存率の改善と関連している可能性があります.
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