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Updated: Jul 12, 2026

In Situ Detection of Autoreactive CD4 T Cells in Brain and Heart Using Major Histocompatibility Complex Class II Dextramers
13:10

In Situ Detection of Autoreactive CD4 T Cells in Brain and Heart Using Major Histocompatibility Complex Class II Dextramers

Published on: August 1, 2014

多発性硬化症における免疫支配的なミエリンベースのタンパク質エピトープのT細胞認識

K Ota1, M Matsui, E L Milford

  • 1Division of Neurology, Brigham and Women's Hospital, Boston, Massachusetts.

Nature
|July 12, 1990
PubMed
まとめ

研究者らは,多発性硬化症 (MS) 患者,特にDR2現象型患者においてT細胞により頻繁に標的となる特定のミエリンベースのタンパク質領域 (残留84-102) を特定した. この発見は,一部の個体におけるMSの病原性を説明する可能性がある.

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