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Updated: Apr 30, 2026

Production of Disulfide-stabilized Transmembrane Peptide Complexes for Structural Studies
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インスリン受容体エクトドメインの構造は,折りたたまれた形状を明らかにします

Neil M McKern1, Michael C Lawrence, Victor A Streltsov

  • 1CSIRO Molecular & Health Technologies, 343 Royal Parade, Parkville, Victoria 3052, Australia.

Nature
|September 8, 2006
PubMed
まとめ

インスリン受容体変異体A (IR-A) エクトドメインの結晶構造は,新しい折りたたみ形状を明らかにします. この発見は,インスリンが受容体と結合する方法を再定義し,高親和性リガンド相互作用のための新しいサイトを暗示しています.

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