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Updated: Jul 10, 2026

Live Cell Calcium Imaging Combined with siRNA Mediated Gene Silencing Identifies Ca2+ Leak Channels in the ER Membrane and their Regulatory Mechanisms
13:40

Live Cell Calcium Imaging Combined with siRNA Mediated Gene Silencing Identifies Ca2+ Leak Channels in the ER Membrane and their Regulatory Mechanisms

Published on: July 7, 2011

プレセニリンはER Ca2+の漏れ経路を形成し,家族性アルツハイマー病に関連した変異によって機能が妨げられます

Huiping Tu1, Omar Nelson, Arseny Bezprozvanny

  • 1Department of Physiology, UT Southwestern Medical Center at Dallas, Dallas, TX 75390, USA.

Cell
|September 9, 2006
PubMed
まとめ

プレセニリンはイオンチャネルを形成し,カルシウム (Ca2+) 信号を調節し,脳の健康に不可欠です. 家族性アルツハイマー病の変異は,この機能を破壊し,アルツハイマー病のCa2+仮説を支持する.

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Implementing Patch Clamp and Live Fluorescence Microscopy to Monitor Functional Properties of Freshly Isolated PKD Epithelium

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A Fluorescence-Based Assay of Membrane Potential for High-Throughput Functional Study of Two Endogenous Ion Channels in Two Epithelial Cell Lines06:59

A Fluorescence-Based Assay of Membrane Potential for High-Throughput Functional Study of Two Endogenous Ion Channels in Two Epithelial Cell Lines

Published on: June 22, 2022

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