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Updated: Jul 6, 2026

Assays for the Degradation of Misfolded Proteins in Cells
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神経退行性疾患のタンパク質アプラタキシンは,中断的なDNA結合中間体を解消する

Ivan Ahel1, Ulrich Rass, Sherif F El-Khamisy

  • 1Cancer Research UK, London Research Institute, Clare Hall Laboratories, South Mimms, Herts EN6 3LD, UK.

Nature
|September 12, 2006
PubMed
まとめ

アプラタキシンは不発性DNA結合を解消し,修復されていないDNA鎖の断裂を防止します. この発見は,APTX遺伝子変異によって引き起こされる神経学的疾患であるアタクシア・オキュロモーター・アプラキシア-1の背後にあるメカニズムを明らかにします.

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