Jove
Visualize
お問い合わせ
JoVE
x logofacebook logolinkedin logoyoutube logo
JoVEについて
概要リーダーシップブログJoVEヘルプセンター
著者向け
出版プロセス編集委員会範囲と方針査読よくある質問投稿
図書館員向け
推薦の声購読アクセスリソース図書館諮問委員会よくある質問
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experimentsアーカイブ
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教員リソースセンター教員サイト
利用規約
プライバシーポリシー
ポリシー

関連する概念動画

Antimicrobial Effectiveness01:28

Antimicrobial Effectiveness

1.1K
The effectiveness of antimicrobial agents depends on various factors influencing their ability to eliminate microbial populations. Larger microbial populations require more time for complete eradication, emphasizing the importance of population size analysis when evaluating antimicrobial efficacy.Microbial resistance to antimicrobial agents varies significantly. Highly resilient microorganisms include endospores, gram-negative bacteria, and non-enveloped viruses, while prions are exceptionally...
1.1K
Biological Methods for Microbial Control01:28

Biological Methods for Microbial Control

941
Biological agents offer an effective means of controlling microbial growth by leveraging natural processes like predation, competition, and the secretion of antimicrobial substances.Predatory bacteria such as Bdellovibrio species target and kill pathogens like Salmonella and E. coli. They are widely used in poultry farms to control infections. Myxococcus species help combat plant-pathogenic fungi. These naturally occurring predators serve as eco-friendly alternatives to chemical pesticides and...
941
Gene Regulation in Microbial Communities: Quorum Sensing01:28

Gene Regulation in Microbial Communities: Quorum Sensing

750
Quorum sensing is a mechanism of bacterial communication that enables coordinated gene expression in response to changes in population density. This facilitates collective behaviors that enhance survival, resource acquisition, and ecological adaptation. This process relies on small signaling molecules called autoinducers that accumulate as bacterial populations grow. When a critical threshold concentration of autoinducers is reached, bacterial cells collectively modify gene expression,...
750
Antimicrobial Proteins01:23

Antimicrobial Proteins

14.7K
Antimicrobial proteins are important components of the immune system. They aid the body in combating pathogens by either killing them directly or hindering their replication processes. Four main types of antimicrobial substances are interferons, the complement system, iron-binding proteins, and antimicrobial proteins.
Interferons
Interferons (IFNs) are proteins produced by lymphocytes, macrophages, and fibroblasts infected with viruses. While IFNs cannot prevent viruses from entering and...
14.7K
Defense Against Bacterial Pathogens01:31

Defense Against Bacterial Pathogens

3.0K
The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
3.0K
Surface Membrane Barriers01:18

Surface Membrane Barriers

3.1K
The skin and mucous membranes serve as the primary line of defense against pathogens by providing both physical and chemical protection. These barriers are essential in preventing the entry and establishment of microbes, thereby maintaining the integrity of the host.
The outer layer of the skin, the epidermis, is a robust barrier comprising layers of closely packed keratinized cells. This dense arrangement prevents microbes from penetrating the body. The periodic shedding of epidermal cells...
3.1K

こちらも読む

関連記事

共著者、ジャーナル、引用グラフによってこの研究に関連する記事。

並び替え
Same author

Correction to "Efficient Protein-Ligand Binding Free Energy Estimation with Coarse-Grained Funnel Metadynamics".

Journal of chemical theory and computation·2026
Same author

Coarse-Grained Simulations Reveal Salt- and Length-Dependent Condensation of G4C2 RNA Repeats.

The journal of physical chemistry letters·2026
Same author

Martini 3 Metabolome.

Journal of chemical theory and computation·2026
Same author

Condensates as Conformation Editors of Disordered Client Proteins.

Journal of the American Chemical Society·2026
Same author

An optimized contact map for GōMartini 3 enabling conformational changes in protein assemblies.

Biophysical journal·2026
Same author

Folded domains impose structural heterogeneity and attenuated dynamics in biomolecular condensates.

Nature communications·2026
Same journal

Switching Site Selectivity in Alkoxyamine Hydration: From Lone-Pair Direction to Solvent Network Dominance.

Journal of the American Chemical Society·2026
Same journal

A Topotactic Leap: 2D Layers to 3D Large-Pore Zeolite.

Journal of the American Chemical Society·2026
Same journal

Enhanced Hydrogen Evolution over Single-Atom Catalysts via Electrostatic Polarization in Contact-electro-catalysis.

Journal of the American Chemical Society·2026
Same journal

Tumor Acidity-Activatable Ionizable Lipid Nanoparticles for Selective Oncolytic Therapy.

Journal of the American Chemical Society·2026
Same journal

Alternating Magnetic Field Promotes Ammonia Cracking by Disrupting the Sabatier Limitation of Ruthenium Catalytic Species.

Journal of the American Chemical Society·2026
Same journal

Bulk Ferromagnetic Icosahedral Quasicrystals without Rapid Quenching.

Journal of the American Chemical Society·2026
関連記事をすべて見る

関連する実験動画

Updated: Feb 22, 2026

Quantifying the Antifungal Activity of Peptides Against Candida albicans
06:45

Quantifying the Antifungal Activity of Peptides Against Candida albicans

Published on: January 13, 2023

2.9K

抗微生物ペプチドが作用している.

Hari Leontiadou1, Alan E Mark, Siewert J Marrink

  • 1Department of Biophysical Chemistry, University of Groningen, Nijenborgh 4, 9747 AG Groningen, The Netherlands.

Journal of the American Chemical Society
|September 14, 2006
PubMed
まとめ
この要約は機械生成です。

マガニンMG-H2のような抗微生物ペプチドは,膜にトロイド状の毛穴を形成する. シミュレーションにより,ペプチドが1つが中心にあり,他のペプチドが毛穴の端に並ぶ新しい毛穴構造が明らかになりました.

さらに関連する動画

Production and Visualization of Bacterial Spheroplasts and Protoplasts to Characterize Antimicrobial Peptide Localization
10:13

Production and Visualization of Bacterial Spheroplasts and Protoplasts to Characterize Antimicrobial Peptide Localization

Published on: August 11, 2018

12.8K
Antimicrobial Peptides Produced by Selective Pressure Incorporation of Non-canonical Amino Acids
11:56

Antimicrobial Peptides Produced by Selective Pressure Incorporation of Non-canonical Amino Acids

Published on: May 4, 2018

13.1K

関連する実験動画

Last Updated: Feb 22, 2026

Quantifying the Antifungal Activity of Peptides Against Candida albicans
06:45

Quantifying the Antifungal Activity of Peptides Against Candida albicans

Published on: January 13, 2023

2.9K
Production and Visualization of Bacterial Spheroplasts and Protoplasts to Characterize Antimicrobial Peptide Localization
10:13

Production and Visualization of Bacterial Spheroplasts and Protoplasts to Characterize Antimicrobial Peptide Localization

Published on: August 11, 2018

12.8K
Antimicrobial Peptides Produced by Selective Pressure Incorporation of Non-canonical Amino Acids
11:56

Antimicrobial Peptides Produced by Selective Pressure Incorporation of Non-canonical Amino Acids

Published on: May 4, 2018

13.1K

科学分野:

  • バイオフィジックス 生物物理学
  • コンピュータ生物学 コンピュータ生物学
  • 膜生物物理学 膜生物物理学

背景:

  • 抗微生物ペプチド (AMP) は,先天的免疫にとって極めて重要です.
  • AMPメカニズムを理解することは,新しい治療法の開発の鍵です.
  • トロイド毛孔モデルは,AMP誘発の膜破壊のための広く受け入れられているメカニズムです.

研究 の 目的:

  • 分子ダイナミクスシミュレーションを使用して,マガイニンMG-H2ペプチドの毛孔形成機構を調査する.
  • 誘導された膜毛孔内のペプチドの構造的組織を解明する.

主な方法:

  • 分子動力学 (MD) シミュレーションが採用されました.
  • シミュレーションは,マガイニンMG-H2ペプチドとモデルフォスホリピド膜の相互作用に焦点を当てた.
  • 協力効果を観察するために複数のペプチドコピーを導入した.

主要な成果:

  • マガニニンMG-H2ペプチドは,フォスフォリピド膜に容易に結合する.
  • 臨界濃度の上では,ペプチドが協力して,ナノメートルのサイズのトロイド状の毛穴を誘導した.
  • 確立されたモデルとは対照的に,典型的には孔の中心に1つのペプチドしか見つかりませんでした.
  • 他のペプチドは,膜に平行して,毛穴の端に集積され,膜に平行して方向づけられています.

結論:

  • この研究では,マガインイン誘発型トロイド毛穴形成の改訂モデルを提示しています.
  • この発見は,AMP-pore構造の従来の理解に挑戦しています.
  • この結果は,抗菌性ペプチドと膜の相互作用の生体物理学に関する新しい洞察を提供します.