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Updated: Jul 11, 2026

Preparation and In Vivo Use of an Activity-based Probe for N-acylethanolamine Acid Amidase
11:01

Preparation and In Vivo Use of an Activity-based Probe for N-acylethanolamine Acid Amidase

Published on: November 23, 2016

システインプロテアゼの有機アジド阻害剤

Giang Thanh Le1, Giovanni Abbenante, Praveen K Madala

  • 1Centre for Drug Design and Development, Institute for Molecular Bioscience, University of Queensland, Brisbane, Qld 4072, Australia.

Journal of the American Chemical Society
|September 21, 2006
PubMed
まとめ

研究者らは,より反応性が低いアジドメチレン基を用いた新しいシステインプロテアース阻害剤を開発した. このアプローチは,安定性の向上と薬物のような性質を持つ強力で可逆的な阻害を提供し,従来の電性阻害剤の毒性の副作用を克服します.

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