妊娠前出血症後の胎児および乳児生存率の動向
Olga Basso1, Svein Rasmussen, Clarice R Weinberg
1Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA. bassoo2@niehs.nih.gov
JAMA
|September 21, 2006
まとめ
妊娠前の不妊症の早期出産は胎児生存率を向上させましたが,新生児死亡リスクは変化しませんでした. この研究では,妊娠前出産の早期出産率の増加が乳児生存結果に与える影響を評価した.
科学分野:
- 産周医学は,産周医学である.
- 産科は産婦人科です.
- ネオナタロジーの新生児科
背景:
- 妊娠前の不妊症の管理には,しばしば早産が伴うため,早産児のリスクを高めます.
- 早期出産率の増加が胎児と乳児の生存率に与える純効果は十分に理解されていません.
研究 の 目的:
- 妊娠前出産における早期出産率の上昇が胎児と乳児の生存に与える影響を評価する.
- 胎児死亡率と新生児死亡率の変化を評価する.
主な方法:
- ノルウェーの登録データ (1967-2003) を用いた人口ベースの観察研究.
- 804,448人の独身初生児を含む.
- 妊娠前出血症に関連して胎児および幼児死亡の確率比率を分析した.
主要な成果:
- 妊娠前出血症の早期誘導 (37週前) は,1967-1978年と1991-2003年の間に8%からほぼ20%に増加しました.
- プレエクレムプティック妊娠における死産リスク (OR) は4.2から1.3に大幅に低下しました.
- 新生児死亡リスク (OR) は安定した (1.7~2.0) 状態で,後の死亡率はほとんど変化しなかった.
結論:
- 妊娠前の妊娠における胎児生存率は,積極的な管理により著しく改善されています.
- 妊娠前出血症による新生児死亡のリスクは,研究期間中に改善しませんでした.
- 持続的な新生児死亡リスクに対処するためにさらなる研究が必要である.
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