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遺伝子治療:IL2RGはT細胞発育において腫瘍性であるのか?

Karin Pike-Overzet1, Dick de Ridder, Floor Weerkamp

  • 1Department of Immunology, Erasmus University Medical Center, 3015 GE Rotterdam, The Netherlands.

Nature
|September 22, 2006
PubMed
まとめ

X-リンクされた重症結合免疫不全 (X-SCID) のインターレウキン-2受容体ガンマ鎖 (IL2RG) 遺伝子治療は,直接腫瘍発生的ではない可能性があります. 代わりに,回復したシグナリングはT細胞の発達を可能にし,LMO2のような腫瘍遺伝子が白血病を促進することを可能にします.

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