転写と転写後の細胞サイクル調節の共進化
Lars Juhl Jensen1, Thomas Skøt Jensen, Ulrik de Lichtenberg
1European Molecular Biology Laboratory, D-69117 Heidelberg, Germany.
Nature
|September 29, 2006
まとめ
細胞周期の遺伝子調節はユカリオット全体で異なっており,異なる生物は異なるタンパク質を使用しています. この進化には,分子機械を組み立てるための転写制御と転写後の制御の両方が含まれています.
科学分野:
- 分子生物学は分子生物学である.
- 遺伝学 遺伝学とは
- 進化生物学の進化生物学について
背景:
- 何百もの遺伝子は,ヒト,酵母,植物を含む多様なエウカリオットのミト細胞サイクル中に定期的に転写されます.
- 細胞サイクルを駆動するタンパク質複合体は,ユカリオット全体で保存されています.
研究 の 目的:
- 細胞周期中の周期的に転写される遺伝子の調節における進化的分岐を調査する.
- 異なった種間の転写および転写後の規制メカニズムを比較する.
主な方法:
- ヒト,芽生えた酵母,分裂酵母,アラビドプシス・タリアナの大規模なDNAマイクロアレイデータセットの比較分析.
- 遺伝子発現パターンとタンパク質のリン酸化データの研究.
主要な成果:
- 核タンパク質複合体は保存されているが,周期的に発現する特定の遺伝子は,生物間では著しく異なる.
- 細胞サイクル遺伝子の転写調節は,異なる系統で独立して進化した.
- 細胞サイクル制御による転写の変化は,しばしばタンパク質のリン酸化パターンの変化と相関する.
結論:
- ユカリオットは,保存された細胞サイクル機構を組み立てるための多様な戦略を進化させた.
- 転写と翻訳後の調節層は,細胞サイクル中の生物システムの動的制御に寄与する.
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