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関連する概念動画

Long-term Potentiation01:35

Long-term Potentiation

51.6K
Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre- and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
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Long-term Depression01:05

Long-term Depression

27.3K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
27.3K
Long-term Potentiation01:25

Long-term Potentiation

2.7K
Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
Hebbian LTP
LTP can occur when...
2.7K
Long-term Depression01:03

Long-term Depression

2.6K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Calcium Ion Concentration Mechanism
If over...
2.6K
Neuroplasticity01:01

Neuroplasticity

2.6K
Neuroplasticity reflects the brain's remarkable capacity to adapt and evolve, responding dynamically to learning, experiences, or injury by reorganizing its neural circuitry. This reorganization involves creating new neural connections and refining old ones through a series of biological processes that contribute to the brain's lifelong development and adaptability.
2.6K
Role of Neurotransmitters in Memory01:23

Role of Neurotransmitters in Memory

2.8K
Neurotransmitters are integral to the brain's communication system, enabling neurons to transmit signals across synapses. This chemical exchange underpins various cognitive functions, including memory processes. The role of neurotransmitters in memory is multifaceted, influencing the encoding, consolidation, and retrieval of memories through their action on different neural circuits.
 Glutamate and Synaptic Plasticity
Glutamate, the brain's main excitatory neurotransmitter, is...
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関連する実験動画

Updated: May 5, 2026

Preparation of Synaptoneurosomes from Mouse Cortex using a Discontinuous Percoll-Sucrose Density Gradient
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Preparation of Synaptoneurosomes from Mouse Cortex using a Discontinuous Percoll-Sucrose Density Gradient

Published on: September 17, 2011

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デンドリット性タンパク質合成,シナプス性可塑性,記憶力

Michael A Sutton1, Erin M Schuman

  • 1Division of Biology 114-96, California Institute of Technology, Howard Hughes Medical Institute, Pasadena, CA 91125, USA.

Cell
|October 5, 2006
PubMed
まとめ
この要約は機械生成です。

ニューロンのデンドライトにおける新しいタンパク質合成は,長期記憶形成に極めて重要です. このレビューでは,これらの重要な記憶タンパク質を作成するためのデンドライトの局所翻訳を支持する証拠を探索します.

さらに関連する動画

3D Modeling of Dendritic Spines with Synaptic Plasticity
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3D Modeling of Dendritic Spines with Synaptic Plasticity

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DetectSyn: A Rapid, Unbiased Fluorescent Method to Detect Changes in Synapse Density
09:10

DetectSyn: A Rapid, Unbiased Fluorescent Method to Detect Changes in Synapse Density

Published on: July 22, 2022

2.9K

関連する実験動画

Last Updated: May 5, 2026

Preparation of Synaptoneurosomes from Mouse Cortex using a Discontinuous Percoll-Sucrose Density Gradient
08:30

Preparation of Synaptoneurosomes from Mouse Cortex using a Discontinuous Percoll-Sucrose Density Gradient

Published on: September 17, 2011

31.5K
3D Modeling of Dendritic Spines with Synaptic Plasticity
07:13

3D Modeling of Dendritic Spines with Synaptic Plasticity

Published on: May 18, 2020

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DetectSyn: A Rapid, Unbiased Fluorescent Method to Detect Changes in Synapse Density
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DetectSyn: A Rapid, Unbiased Fluorescent Method to Detect Changes in Synapse Density

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科学分野:

  • 神経科学は神経科学である.
  • 分子生物学は分子生物学である.
  • 細胞生物学 細胞生物学

背景:

  • 長期記憶 (LTM) の形成は,新しいタンパク質の合成に依存しています.
  • このタンパク質合成の正確な位置は,活発な研究分野です.

研究 の 目的:

  • ニューロンのデンドライトにおける局所タンパク質合成を支持する実験的証拠をレビューする.
  • 記憶における dendritic ローカルトランスレーションに関する未解決の問題を特定する.

主な方法:

  • タンパク質合成と記憶に関する既存の実験研究のレビュー.
  • ニューロンの可塑性や dendritic translationに関連するデータの分析.

主要な成果:

  • 増加する証拠は,ニューロンのデンドライト内の局所的なタンパク質合成の仮説を支持しています.
  • 局所的に合成される特定のタンパク質は,シナプス性可塑性と記憶の統合に関与しています.

結論:

  • デンドライトにおける局所翻訳は,長期記憶に貢献する重要なメカニズムである.
  • 関連する分子プレーヤーと規制メカニズムを完全に解明するには,さらなる研究が必要です.