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Updated: Jul 14, 2026

In Vivo Modeling of the Morbid Human Genome using Danio rerio
12:31

In Vivo Modeling of the Morbid Human Genome using Danio rerio

Published on: August 24, 2013

in vivo から in silico 生物学,そしてその逆へ

Barbara Di Ventura1, Caroline Lemerle, Konstantinos Michalodimitrakis

  • 1European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany.

Nature
|October 7, 2006
PubMed
まとめ

生物学的システムのシミュレーションは,複雑なデータを理解するためにますます重要になっています. その利点と限界を認識することは,実験者が日常の研究でこれらの計算ツールを採用するのに役立ちます.

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Synthetic Biology

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In pharmaceutical development, it's crucial to establish a predictive in vitro–in vivo correlation (IVIVC) for two or more formulations to gain a comprehensive understanding of release properties. IVIVC reduces the need for costly in vivo studies and facilitates the establishment of meaningful dissolution specifications with significant cost savings and decreased regulatory burden. Furthermore, a meaningful IVIVC should predict Cmax and AUC within 20%, aligning with FDA guidance while adhering...