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Updated: Jul 16, 2026

Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs
10:44

Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs

Published on: May 15, 2019

AB5サブティラゼサイトトキシンは,エンドプラズマ網膜のチャペロンBiPを無効化する

Adrienne W Paton1, Travis Beddoe, Cheleste M Thorpe

  • 1School of Molecular and Biomedical Science, University of Adelaide, South Australia 5005, Australia. adrienne.paton@adelaide.edu.au

Nature
|October 7, 2006
PubMed
まとめ

バクテリアの毒素であるサブティラゼ・サイトトキシン (Subtilase cytotoxin) は,必要不可欠なエンドプラズマ網膜のチャペロンBiP/GRP78.8を割って細胞死を誘発する. この特定の割れ目が正常な細胞機能を破壊し,細菌の病原性の新しいメカニズムを強調しています.

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