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Updated: Jul 5, 2026

A New Screening Method for the Directed Evolution of Thermostable Bacteriolytic Enzymes
13:30

A New Screening Method for the Directed Evolution of Thermostable Bacteriolytic Enzymes

Published on: November 7, 2012

OPLSAAとCHARMMの両方の力場による変異型リゾ酵素の熱変性化

Maria Eleftheriou1, Robert S Germain, Ajay K Royyuru

  • 1Computational Biology Center, Deep Computing Institute, IBM Watson Research Center, Yorktown Heights, NY 10598, USA.

Journal of the American Chemical Society
|October 13, 2006
PubMed
まとめ

ハンリゾ酵素 (TRP62GLY) の単一の突然変異は,タンパク質の安定性を著しく低下させ,分子動力学シミュレーションによって確認されたように,誤折り経路を変更します. これらの発見は実験データと一致し,突然変異を強調しています.

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Cooperative Allosteric Transitions01:58

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