牛皮病患者の心筋梗塞のリスク
Joel M Gelfand1, Andrea L Neimann, Daniel B Shin
1Department of Dermatology and Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, PA 19104, USA. joel.gelfand@uphs.upenn.edu
JAMA
|October 13, 2006
まとめ
牛皮病は,心筋梗塞 (MI) の独立した危険因子です. 重症の牛皮を患っている若い患者は,心臓発作のリスクが最も高く,このTヘルパー細胞型1型疾患の心血管への影響を強調しています.
科学分野:
- 免疫皮膚病学について
- 心血管伝染病学 心血管伝染病学
- 公衆衛生は公衆衛生である.
背景:
- Tヘルパー細胞1型 (T(H) 1型) の免疫疾患である牛皮病は,心血管疾患に関連している.
- 前回のソーリアーシスと心血管疾患に関する研究は,病院で行われ,主要な危険因子に対するコントロールが欠けていました.
研究 の 目的:
- 人口ベースのコホートにおいて,牛皮病が心筋梗塞 (MI) の独立したリスク因子であるかどうかを調査する.
- 牛皮の重症度と心筋梗塞のリスクとの関連性を評価し,心血管疾患の危険因子を制御する.
主な方法:
- イギリス (1987年-2002年) で55万6千人を対象に実施された前向きな,人口ベースのコホート研究.
- 軽症/重症の牛皮肉症患者のMI発生率と対照群の比較,高血圧,糖尿病,高脂血症,年齢,性別,喫煙,BMIを調整した.
- システミック療法の使用に基づくソーリアーシスの重度の分類;平均フォローアップ期間は5.4年でした.
主要な成果:
- 牛皮肉症の患者は,心筋梗塞の調整された相対リスク (RR) の増加を示した.
- 30歳の人の場合,心筋梗塞のRRは1.29 (軽症) と3.10 (重症) でした.
- 60歳の人の場合,心筋梗塞のRRは1.08 (軽症) と1.36 (重症) でした.
結論:
- 牛皮病は,心筋梗塞 (MI) の独立した危険因子であるようです.
- 牛皮病に関連したMIの相対的なリスクは,若い人,特に重度の疾患を有する人において著しく高くなります.
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